4lvb

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'''Unreleased structure'''
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{{STRUCTURE_4lvb| PDB=4lvb | SCENE= }}
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===Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)===
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{{ABSTRACT_PUBMED_24021463}}
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The entry 4lvb is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
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Authors: Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O' Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
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==About this Structure==
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[[4lvb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVB OCA].
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Description: Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
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==Reference==
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<ref group="xtra">PMID:024021463</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Nicotinamide phosphoribosyltransferase]]
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[[Category: Bravo, B.]]
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[[Category: Brien, T O.]]
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[[Category: Dragovich, P S.]]
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[[Category: Feng, Y.]]
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[[Category: Giannetti, A M.]]
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[[Category: Gunzner-Toste, J.]]
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[[Category: Ho, Y.]]
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[[Category: Hua, R.]]
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[[Category: Liederer, B M.]]
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[[Category: Liu, Y.]]
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[[Category: Oeh, J.]]
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[[Category: Sampath, D.]]
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[[Category: Shen, Y.]]
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[[Category: Skelton, N.]]
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[[Category: Wang, C.]]
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[[Category: Wang, L.]]
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[[Category: Wang, W.]]
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[[Category: Wu, H.]]
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[[Category: Xiao, Y.]]
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[[Category: Yuen, P.]]
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[[Category: Zak, M.]]
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[[Category: Zhao, G.]]
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[[Category: Zhao, Q.]]
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[[Category: Zheng, X.]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 08:12, 29 September 2013

Template:STRUCTURE 4lvb

Contents

Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Template:ABSTRACT PUBMED 24021463

Function

[NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

About this Structure

4lvb is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Zheng X, Bair KW, Bauer P, Baumeister T, Bowman KK, Buckmelter AJ, Caligiuri M, Clodfelter KH, Feng Y, Han B, Ho YC, Kley N, Li H, Liang X, Liederer BM, Lin J, Ly J, O'Brien T, Oeh J, Oh A, Reynolds DJ, Sampath D, Sharma G, Skelton N, Smith CC, Tremayne J, Wang L, Wang W, Wang Z, Wu H, Wu J, Xiao Y, Yang G, Yuen PW, Zak M, Dragovich PS. Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett. 2013 Oct 15;23(20):5488-97. doi:, 10.1016/j.bmcl.2013.08.074. Epub 2013 Aug 22. PMID:24021463 doi:10.1016/j.bmcl.2013.08.074

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OCA

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