4h8i

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'''Unreleased structure'''
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{{STRUCTURE_4h8i| PDB=4h8i | SCENE= }}
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===Structure of GluK2-LBD in complex with GluAzo===
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The entry 4h8i is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/GRIK2_RAT GRIK2_RAT]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).<ref>PMID:17486098</ref> <ref>PMID:17115050</ref>
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Authors: Reiter, A., Skerra, A., Trauner, D., Schiefner, A.
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==About this Structure==
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[[4h8i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H8I OCA].
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Description: Structure of GluK2-LBD in complex with GluAzo
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Rattus norvegicus]]
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[[Category: Reiter, A.]]
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[[Category: Schiefner, A.]]
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[[Category: Skerra, A.]]
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[[Category: Trauner, D.]]
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[[Category: Gluazo]]
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[[Category: Glycoprotein]]
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[[Category: Ion channel]]
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[[Category: Ion transport]]
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[[Category: Ionotropic glutamate receptor]]
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[[Category: Kainate receptor]]
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[[Category: Ligand-binding domain]]
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[[Category: Membrane protein]]
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[[Category: Me]]
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[[Category: Pcl]]
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[[Category: Photochromic ligand]]
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[[Category: Postsynaptic cell membrane]]
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[[Category: Presynaptic cell membrane]]
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[[Category: Signaling protein]]
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[[Category: Synapse]]
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[[Category: Transmembrane protein]]

Revision as of 08:17, 29 September 2013

Template:STRUCTURE 4h8i

Contents

Structure of GluK2-LBD in complex with GluAzo

Function

[GRIK2_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).[1] [2]

About this Structure

4h8i is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Martin S, Nishimune A, Mellor JR, Henley JM. SUMOylation regulates kainate-receptor-mediated synaptic transmission. Nature. 2007 May 17;447(7142):321-5. Epub 2007 May 7. PMID:17486098 doi:nature05736
  2. ↑ Weston MC, Schuck P, Ghosal A, Rosenmund C, Mayer ML. Conformational restriction blocks glutamate receptor desensitization. Nat Struct Mol Biol. 2006 Dec;13(12):1120-7. Epub 2006 Nov 19. PMID:17115050 doi:http://dx.doi.org/10.1038/nsmb1178

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