2oi4

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==Overview==
==Overview==
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A general route to ruthenium pyridocarbazole half-sandwich complexes is, presented and applied to the synthesis of sixteen new compounds, many of, which have modulated protein kinase inhibition properties. For example, the incorporation of a fluorine into the pyridine moiety increases the, binding affinity for glycogen synthase kinase 3 by almost one order of, magnitude. These data are supplemented with cyclic voltammetry experiments, and a protein co-crystallographic study.
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A general route to ruthenium pyridocarbazole half-sandwich complexes is presented and applied to the synthesis of sixteen new compounds, many of which have modulated protein kinase inhibition properties. For example, the incorporation of a fluorine into the pyridine moiety increases the binding affinity for glycogen synthase kinase 3 by almost one order of magnitude. These data are supplemented with cyclic voltammetry experiments and a protein co-crystallographic study.
==About this Structure==
==About this Structure==
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[[Category: transferase]]
[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:03:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:18:59 2008''

Revision as of 16:19, 21 February 2008

Image:2oi4.gif

2oi4, resolution 2.20Å

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Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole

Overview

A general route to ruthenium pyridocarbazole half-sandwich complexes is presented and applied to the synthesis of sixteen new compounds, many of which have modulated protein kinase inhibition properties. For example, the incorporation of a fluorine into the pyridine moiety increases the binding affinity for glycogen synthase kinase 3 by almost one order of magnitude. These data are supplemented with cyclic voltammetry experiments and a protein co-crystallographic study.

About this Structure

2OI4 is a Single protein structure of sequence from Homo sapiens with , , and as ligands. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.

Reference

Ruthenium half-sandwich complexes as protein kinase inhibitors: derivatization of the pyridocarbazole pharmacophore ligand., Pagano N, Maksimoska J, Bregman H, Williams DS, Webster RD, Xue F, Meggers E, Org Biomol Chem. 2007 Apr 21;5(8):1218-27. Epub 2007 Mar 20. PMID:17406720

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