4gv5

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==Function==
==Function==
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[[http://www.uniprot.org/uniprot/MYX_CRODR MYX_CRODR]] This toxin specifically modifies voltage-gated sodium channels (Nav), it exhibits analgesic activity. Moreover, it actively interacts with lipid membranes (By similarity). It induces severe myonecrosis accompanied by edema and hemorrhage.
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[[http://www.uniprot.org/uniprot/MYXC_CRODU MYXC_CRODU]] This toxin specifically modifies voltage-gated sodium channels (Nav), it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes.<ref>PMID:1176086</ref> <ref>PMID:9839677</ref>
==About this Structure==
==About this Structure==
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[[4gv5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_durissus_ruruima Crotalus durissus ruruima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV5 OCA].
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[[4gv5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_durissus_terrificus Crotalus durissus terrificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV5 OCA].
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[[Category: Crotalus durissus ruruima]]
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Crotalus durissus terrificus]]
[[Category: Arni, R K.]]
[[Category: Arni, R K.]]
[[Category: Betzel, C.]]
[[Category: Betzel, C.]]

Revision as of 05:58, 2 October 2013

Template:STRUCTURE 4gv5

Contents

X-ray structure of crotamine, a cell-penetrating peptide from the Brazilian snake Crotalus durissus terrificus

Function

[MYXC_CRODU] This toxin specifically modifies voltage-gated sodium channels (Nav), it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes.[1] [2]

About this Structure

4gv5 is a 3 chain structure with sequence from Crotalus durissus terrificus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Laure CJ. [The primary structure of crotamine (author's transl)]. Hoppe Seylers Z Physiol Chem. 1975 Feb;356(2):213-5. PMID:1176086
  2. ↑ Mancin AC, Soares AM, Andriao-Escarso SH, Faca VM, Greene LJ, Zuccolotto S, Pela IR, Giglio JR. The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon. 1998 Dec;36(12):1927-37. PMID:9839677

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