4m49
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_4m49| PDB=4m49 | SCENE= }} | {{STRUCTURE_4m49| PDB=4m49 | SCENE= }} | ||
===Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18=== | ===Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18=== | ||
| + | {{ABSTRACT_PUBMED_24012183}} | ||
==Disease== | ==Disease== | ||
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==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024012183</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: L-lactate dehydrogenase]] | [[Category: L-lactate dehydrogenase]] | ||
Revision as of 05:59, 2 October 2013
Contents |
Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18
Template:ABSTRACT PUBMED 24012183
Disease
[LDHA_HUMAN] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.[1]
About this Structure
4m49 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Fauber BP, Dragovich PS, Chen J, Corson LB, Ding CZ, Eigenbrot C, Giannetti AM, Hunsaker T, Labadie S, Liu Y, Liu Y, Malek S, Peterson D, Pitts K, Sideris S, Ultsch M, Vanderporten E, Wang J, Wei B, Yen I, Yue Q. Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5533-9. doi: 10.1016/j.bmcl.2013.08.060., Epub 2013 Aug 22. PMID:24012183 doi:10.1016/j.bmcl.2013.08.060
