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3rdp
From Proteopedia
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| - | [[Image:3rdp.png|left|200px]] | ||
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{{STRUCTURE_3rdp| PDB=3rdp | SCENE= }} | {{STRUCTURE_3rdp| PDB=3rdp | SCENE= }} | ||
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===Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with N-METHYL-FHBT=== | ===Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with N-METHYL-FHBT=== | ||
| + | {{ABSTRACT_PUBMED_21623543}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3rdp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3rdp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type 1 / strain 17)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDP OCA]. |
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021623543</ref>< | + | <ref group="xtra">PMID:021623543</ref><references group="xtra"/><references/> |
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[[Category: Thymidine kinase]] | [[Category: Thymidine kinase]] | ||
[[Category: Ametamey, S.]] | [[Category: Ametamey, S.]] | ||
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[[Category: Perozzo, R.]] | [[Category: Perozzo, R.]] | ||
[[Category: Scapozza, L.]] | [[Category: Scapozza, L.]] | ||
| + | [[Category: Westermaier, Y.]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Dna synthesis]] | [[Category: Dna synthesis]] | ||
Revision as of 06:01, 2 October 2013
Contents |
Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with N-METHYL-FHBT
Template:ABSTRACT PUBMED 21623543
Function
[KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
About this Structure
3rdp is a 2 chain structure with sequence from Herpes simplex virus (type 1 / strain 17). Full crystallographic information is available from OCA.
See Also
Reference
- Martic M, Pernot L, Westermaier Y, Perozzo R, Kraljevic TG, Kristafor S, Raic-Malic S, Scapozza L, Ametamey S. Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo. Nucleosides Nucleotides Nucleic Acids. 2011 Apr;30(4):293-315. PMID:21623543 doi:10.1080/15257770.2011.581258
