2yjt
From Proteopedia
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===Crystal structure of E. coli DEAD-box protein SrmB bound to regulator of ribonuclease activity A (RraA)=== | ===Crystal structure of E. coli DEAD-box protein SrmB bound to regulator of ribonuclease activity A (RraA)=== | ||
| + | {{ABSTRACT_PUBMED_24045937}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/D8AM26_ECOLX D8AM26_ECOLX]] Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity).[HAMAP-Rule:MF_00471][SAAS:SAAS005493_004_044335] [[http://www.uniprot.org/uniprot/SRMB_ECOLI SRMB_ECOLI]] DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity. Acts before DeaD.<ref>PMID:12787353</ref> <ref>PMID:15196029</ref> <ref>PMID:15148362</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | [[2yjt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[2yjt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJT OCA]. |
| - | [[Category: Escherichia coli]] | + | |
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:024045937</ref><references group="xtra"/><references/> | ||
| + | [[Category: Escherichia coli k-12]] | ||
[[Category: RNA helicase]] | [[Category: RNA helicase]] | ||
[[Category: Hardwick, S W.]] | [[Category: Hardwick, S W.]] | ||
Revision as of 06:11, 2 October 2013
Contents |
Crystal structure of E. coli DEAD-box protein SrmB bound to regulator of ribonuclease activity A (RraA)
Template:ABSTRACT PUBMED 24045937
Function
[D8AM26_ECOLX] Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity).[HAMAP-Rule:MF_00471][SAAS:SAAS005493_004_044335] [SRMB_ECOLI] DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity. Acts before DeaD.[1] [2] [3]
About this Structure
2yjt is a 4 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.
Reference
- Pietras Z, Hardwick SW, Swiezewski S, Luisi BF. Potential regulatory interactions of Escherichia coli RraA protein with DEAD-box helicases. J Biol Chem. 2013 Sep 17. PMID:24045937 doi:10.1074/jbc.M113.502146
- ↑ Charollais J, Pflieger D, Vinh J, Dreyfus M, Iost I. The DEAD-box RNA helicase SrmB is involved in the assembly of 50S ribosomal subunits in Escherichia coli. Mol Microbiol. 2003 Jun;48(5):1253-65. PMID:12787353
- ↑ Bizebard T, Ferlenghi I, Iost I, Dreyfus M. Studies on three E. coli DEAD-box helicases point to an unwinding mechanism different from that of model DNA helicases. Biochemistry. 2004 Jun 22;43(24):7857-66. PMID:15196029 doi:10.1021/bi049852s
- ↑ Charollais J, Dreyfus M, Iost I. CsdA, a cold-shock RNA helicase from Escherichia coli, is involved in the biogenesis of 50S ribosomal subunit. Nucleic Acids Res. 2004 May 17;32(9):2751-9. Print 2004. PMID:15148362 doi:10.1093/nar/gkh603
