4k77

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-	'''Unreleased structure'''	+	{{STRUCTURE_4k77| PDB=4k77 | SCENE= }}
		+	===JAK1 kinase (JH1 domain) in complex with compound 6===
		+	{{ABSTRACT_PUBMED_24042009}}
-	The entry 4k77 is ON HOLD until Paper Publication	+	==Function==
		+	[[http://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
-	Authors: Eigenbrot, C., Shia, S.	+	==About this Structure==
		+	[[4k77]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K77 OCA].
-	Description: JAK1 kinase (JH1 domain) in complex with compound 6	+	==Reference==
		+	<ref group="xtra">PMID:024042009</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Non-specific protein-tyrosine kinase]]
		+	[[Category: Eigenbrot, C.]]
		+	[[Category: Shia, S.]]
		+	[[Category: Phosphotransfer]]
		+	[[Category: Protein kinase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

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Revision as of 07:20, 2 October 2013

Template:STRUCTURE 4k77

Contents 1 JAK1 kinase (JH1 domain) in complex with compound 6 2 Function 3 About this Structure 4 Reference

JAK1 kinase (JH1 domain) in complex with compound 6

Template:ABSTRACT PUBMED 24042009

Function

[JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

About this Structure

4k77 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Labadie S, Barrett K, Blair WS, Chang C, Deshmukh G, Eigenbrot C, Gibbons P, Johnson A, Kenny JR, Kohli PB, Liimatta M, Lupardus PJ, Shia S, Steffek M, Ubhayakar S, Abbema AV, Zak M. Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors. Bioorg Med Chem Lett. 2013 Aug 27. pii: S0960-894X(13)01022-6. doi:, 10.1016/j.bmcl.2013.08.082. PMID:24042009 doi:10.1016/j.bmcl.2013.08.082