4k6z

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'''Unreleased structure'''
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{{STRUCTURE_4k6z| PDB=4k6z | SCENE= }}
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===The Jak1 kinase domain in complex with compound 37===
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{{ABSTRACT_PUBMED_24042009}}
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The entry 4k6z is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
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Authors: Fong, R., Lupardus, P.J.
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==About this Structure==
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[[4k6z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6Z OCA].
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Description: The Jak1 kinase domain in complex with compound 37
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==Reference==
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<ref group="xtra">PMID:024042009</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Fong, R.]]
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[[Category: Lupardus, P J.]]
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[[Category: Kinase]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 07:21, 2 October 2013

Template:STRUCTURE 4k6z

Contents

The Jak1 kinase domain in complex with compound 37

Template:ABSTRACT PUBMED 24042009

Function

[JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

About this Structure

4k6z is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Labadie S, Barrett K, Blair WS, Chang C, Deshmukh G, Eigenbrot C, Gibbons P, Johnson A, Kenny JR, Kohli PB, Liimatta M, Lupardus PJ, Shia S, Steffek M, Ubhayakar S, Abbema AV, Zak M. Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors. Bioorg Med Chem Lett. 2013 Aug 27. pii: S0960-894X(13)01022-6. doi:, 10.1016/j.bmcl.2013.08.082. PMID:24042009 doi:10.1016/j.bmcl.2013.08.082

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OCA

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