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4lix

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m (Protected "4lix" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4lix| PDB=4lix | SCENE= }}
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===Crystal structure of ent-copalyl diphosphate synthase from Arabidopsis thaliana in complex with (S)-15-aza-14,15-dihydrogeranylgeranyl thiolodiphosphate at 1.55 A resolution===
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{{ABSTRACT_PUBMED_24036329}}
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The entry 4lix is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/KSA_ARATH KSA_ARATH]] Catalyzes the conversion of geranylgeranyl diphosphate to the gibberellin precursor ent-copalyl diphosphate.<ref>PMID:17457817</ref> <ref>PMID:20430888</ref>
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Authors: Koksal, M., Christianson, D.W.
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==About this Structure==
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[[4lix]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ochroconis_lascauxensis Ochroconis lascauxensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LIX OCA].
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Description: Crystal structure of ent-copalyl diphosphate synthase from Arabidopsis thaliana in complex with (S)-15-aza-14,15-dihydrogeranylgeranyl thiolodiphosphate at 1.55 A resolution
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==Reference==
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<ref group="xtra">PMID:024036329</ref><references group="xtra"/><references/>
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[[Category: Ent-copalyl diphosphate synthase]]
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[[Category: Ochroconis lascauxensis]]
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[[Category: Christianson, D W.]]
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[[Category: Koksal, M.]]
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[[Category: Biosynthesis of ent-copalyl diphosphate]]
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[[Category: Class i and ii terpene cyclase fold]]
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[[Category: Class ii diterpene cyclase]]
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[[Category: Dxdd motif]]
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[[Category: Gibberellin biosynthesis]]
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[[Category: Isomerase]]

Revision as of 07:22, 2 October 2013

Template:STRUCTURE 4lix

Contents

Crystal structure of ent-copalyl diphosphate synthase from Arabidopsis thaliana in complex with (S)-15-aza-14,15-dihydrogeranylgeranyl thiolodiphosphate at 1.55 A resolution

Template:ABSTRACT PUBMED 24036329

Function

[KSA_ARATH] Catalyzes the conversion of geranylgeranyl diphosphate to the gibberellin precursor ent-copalyl diphosphate.[1] [2]

About this Structure

4lix is a 1 chain structure with sequence from Ochroconis lascauxensis. Full crystallographic information is available from OCA.

Reference

  • Koksal M, Potter K, Peters RJ, Christianson DW. 1.55A-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis. Biochim Biophys Acta. 2013 Sep 12. pii: S0304-4165(13)00379-6. doi:, 10.1016/j.bbagen.2013.09.004. PMID:24036329 doi:10.1016/j.bbagen.2013.09.004
  1. ↑ Prisic S, Xu J, Coates RM, Peters RJ. Probing the role of the DXDD motif in Class II diterpene cyclases. Chembiochem. 2007 May 25;8(8):869-74. PMID:17457817 doi:10.1002/cbic.200700045
  2. ↑ Mann FM, Prisic S, Davenport EK, Determan MK, Coates RM, Peters RJ. A single residue switch for Mg(2+)-dependent inhibition characterizes plant class II diterpene cyclases from primary and secondary metabolism. J Biol Chem. 2010 Jul 2;285(27):20558-63. doi: 10.1074/jbc.M110.123307. Epub 2010, Apr 29. PMID:20430888 doi:10.1074/jbc.M110.123307

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