1w5u

From Proteopedia

Revision as of 14:21, 30 October 2007

GRAMICIDIN D FROM BACILLUS BREVIS (ETHANOL SOLVATE)

Overview

Gramicidin D (gD) is a naturally occurring ionophoric antibiotic that, forms membrane channels specific for monovalent cations. The crystal, structure of the RbCl complex of gD has been determined at 1.14 A, resolution from low-temperature (100 K) synchrotron-radiation data with a, final R of 16%. The structure was refined with anisotropic temperature, factors for all non-H atoms and with partial occupancies for many of them., The asymmetric unit in the crystal contains four crystallographically, independent molecules that form two right-handed antiparallel, double-stranded dimers. There are seven distinct rubidium-binding sites in, each dimeric channel. The occupancy factors of Rb cations are between 0.11, and 0.35 and the total ion contents of the two crystallographically, independent ... [(full description)]

About this Structure

1W5U is a [Single protein] structure of sequence from [Brevibacillus brevis] with RB, CL, FOR and EOH as [ligands]. Structure known Active Site: AC9. Full crystallographic information is available from [OCA].

Reference

Structure of gramicidin D-RbCl complex at atomic resolution from low-temperature synchrotron data: interactions of double-stranded gramicidin channel contents and cations with channel wall., Glowka ML, Olczak A, Bojarska J, Szczesio M, Duax WL, Burkhart BM, Pangborn WA, Langs DA, Wawrzak Z, Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):433-41. Epub 2005, Mar 24. PMID:15805598

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