4hqj

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'''Unreleased structure'''
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{{STRUCTURE_4hqj| PDB=4hqj | SCENE= }}
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===Crystal structure of Na+,K+-ATPase in the Na+-bound state===
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{{ABSTRACT_PUBMED_24051246}}
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The entry 4hqj is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/AT1A1_PIG AT1A1_PIG]] This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. [[http://www.uniprot.org/uniprot/AT1B1_PIG AT1B1_PIG]] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
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Authors: Nyblom, M., Reinhard, L., Gourdon, P., Nissen, P.
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==About this Structure==
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[[4hqj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQJ OCA].
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Description: P-type ATPase crystal structure
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==Reference==
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<ref group="xtra">PMID:024051246</ref><references group="xtra"/><references/>
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[[Category: Sodium/potassium-exchanging ATPase]]
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[[Category: Sus scrofa]]
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[[Category: Gourdon, P.]]
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[[Category: Nissen, P.]]
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[[Category: Nyblom, M.]]
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[[Category: Reinhard, L.]]
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[[Category: Hydrolase-transport protein complex]]
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[[Category: Membrane protein]]
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[[Category: Na+/k+ transport]]

Revision as of 07:26, 2 October 2013

Template:STRUCTURE 4hqj

Contents

Crystal structure of Na+,K+-ATPase in the Na+-bound state

Template:ABSTRACT PUBMED 24051246

Function

[AT1A1_PIG] This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. [AT1B1_PIG] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.

About this Structure

4hqj is a 6 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

  • Nyblom M, Poulsen H, Gourdon P, Reinhard L, Andersson M, Lindahl E, Fedosova N, Nissen P. Crystal Structure of Na+, K+-ATPase in the Na+-Bound State. Science. 2013 Sep 19. PMID:24051246 doi:10.1126/science.1243352

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