4m6w

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'''Unreleased structure'''
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{{STRUCTURE_4m6w| PDB=4m6w | SCENE= }}
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===Crystal structure of the C-terminal segment of FANCM in complex with FAAP24===
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{{ABSTRACT_PUBMED_24003026}}
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The entry 4m6w is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.
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Authors: Yang, H., Zhang, T., Tong, L., Ding, J.
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==Function==
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[[http://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN]] ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.<ref>PMID:16116422</ref> <ref>PMID:16116434</ref> [REFERENCE:7][REFERENCE:8] [[http://www.uniprot.org/uniprot/FAP24_HUMAN FAP24_HUMAN]] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.
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Description: Crystal structure of the C-terminal segment of FANCM in complex with FAAP24
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==About this Structure==
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[[4m6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6W OCA].
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==Reference==
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<ref group="xtra">PMID:024003026</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: RNA helicase]]
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[[Category: Ding, J.]]
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[[Category: Tong, L.]]
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[[Category: Yang, H.]]
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[[Category: Zhang, T.]]
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[[Category: Dna binding protein]]
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[[Category: Dna repair]]
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[[Category: Faap24]]
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[[Category: Fancm]]
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[[Category: Fanconi anemia]]
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[[Category: Xpf/mus81]]

Revision as of 07:28, 2 October 2013

Template:STRUCTURE 4m6w

Contents

Crystal structure of the C-terminal segment of FANCM in complex with FAAP24

Template:ABSTRACT PUBMED 24003026

Disease

[FANCM_HUMAN] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.

Function

[FANCM_HUMAN] ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.[1] [2] [REFERENCE:7][REFERENCE:8] [FAP24_HUMAN] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.

About this Structure

4m6w is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Yang H, Zhang T, Tao Y, Wang F, Tong L, Ding J. Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair. Nucleic Acids Res. 2013 Sep 3. PMID:24003026 doi:10.1093/nar/gkt788
  1. ↑ Meetei AR, Medhurst AL, Ling C, Xue Y, Singh TR, Bier P, Steltenpool J, Stone S, Dokal I, Mathew CG, Hoatlin M, Joenje H, de Winter JP, Wang W. A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat Genet. 2005 Sep;37(9):958-63. Epub 2005 Aug 21. PMID:16116422 doi:ng1626
  2. ↑ Mosedale G, Niedzwiedz W, Alpi A, Perrina F, Pereira-Leal JB, Johnson M, Langevin F, Pace P, Patel KJ. The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway. Nat Struct Mol Biol. 2005 Sep;12(9):763-71. Epub 2005 Aug 21. PMID:16116434 doi:10.1038/nsmb981

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