4j6s

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'''Unreleased structure'''
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{{STRUCTURE_4j6s| PDB=4j6s | SCENE= }}
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===14-3-3gamma complexed with the N-terminal sequence of tyrosine hydroxylase (residues 1-43)===
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The entry 4j6s is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/1433G_HUMAN 1433G_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:16511572</ref>
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Authors: Mileni, M., Martinez, A., Stevens, R.C.
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==About this Structure==
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[[4j6s]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6S OCA].
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Description: 14-3-3gamma complexed with the N-terminal sequence of tyrosine hydroxylase (residues 1-43)
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Tyrosine 3-monooxygenase]]
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[[Category: Martinez, A.]]
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[[Category: Mileni, M.]]
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[[Category: Stevens, R C.]]
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[[Category: 14-3-3 protein]]
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[[Category: Dopamine synthesis]]
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[[Category: Hydrolase]]
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[[Category: Peptide binding]]
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[[Category: Phosphorylation]]
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[[Category: Regulatory protein]]
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[[Category: Signal transduction]]
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[[Category: Tyrosine hydroxylase]]

Revision as of 07:34, 2 October 2013

Template:STRUCTURE 4j6s

Contents

14-3-3gamma complexed with the N-terminal sequence of tyrosine hydroxylase (residues 1-43)

Function

[1433G_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.[1]

About this Structure

4j6s is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Jin Y, Dai MS, Lu SZ, Xu Y, Luo Z, Zhao Y, Lu H. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J. 2006 Mar 22;25(6):1207-18. Epub 2006 Mar 2. PMID:16511572 doi:10.1038/sj.emboj.7601010

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OCA

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