Topoisomerase binding protein

Topoisomerase binding protein (TopBP1) interacts with the C-terminal of topoisomerase II beta. TopBP1 is required for DNA replication. It binds double-stranded DNA breaks and nicks and plays a role in rescuing stalled DNA replication forks. TopBP1 contains BRCT domains which are ca. 100 amino acid long tandem repeat which bind phosphor-peptides.

3D structures of topoisomerase binding protein

Updated on 06-October-2013

3jve, 3pd7 – hTopBP1 BRCT 6 domain – human

2xnh, 2xnk – hTopBP1 BRCT 0-2 domains
3olc – hTopBP1 N terminal
3uen – hTopBP1 BRCT 4-5 domains
3ueo – hTopBP1 BRCT 4-5 domains + phosphor-peptide
3al2 – hTopBP1 BRCT 7-8 domains
3al3 – hTopBP1 BRCT 7-8 domains + Fanconi anemia group J protein peptide