Kinesin
From Proteopedia
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | ===Kinesin | + | ===Kinesin heavy chain (KIF)=== |
| - | [[2wbe]] – cKIF MD+FNL+Tubulin A+Tubulin B+AMPPNP – cow <br /> | ||
| - | [[1ia0]] – KIF1A MD+Tubulin A+Tubulin B+ATP - pig<br /> | ||
| - | [[3gbj]] – hKIF13B MD+ADP – human<br /> | ||
| - | [[3edl]] – cKIF MD+ Tubulin A+Tubulin B – EM<br /> | ||
[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br /> | [[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br /> | ||
| - | [[1vfv]], [[1vfw]] – mKIF1A MD+Mg-AMPPNP<br /> | ||
| - | [[1vfx]] - mKIF1A MD+ADP-Mg-AlFx<br /> | ||
| - | [[1vfz]] - mKIF1A MD+ADP-Mg-VO4<br /> | ||
| - | [[1v8j]] – mKIF2C MD+Mg-ADP<br /> | ||
| - | [[1i5s]] - mKIF2C MD (mutant)+Mg-ADP<br /> | ||
| - | [[1i6i]] - mKIF2C MD (mutant)+Mg-AMPPCP<br /> | ||
| - | [[1v8k]] - mKIF2C MD+Mg-AMPPNP<br /> | ||
| - | [[4hna]] – hKIF1 + Tubulin A + Tubulin B + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br /> | ||
| - | [[2p4n]] – hKIF+ Tubulin A+TubulinB – EM docking<br /> | ||
[[2vvg]] – KIF2 MD – ''Giardia intestinalis''<br /> | [[2vvg]] – KIF2 MD – ''Giardia intestinalis''<br /> | ||
| - | [[2cjo]] – hKIF13+inhibitor 30<br /> | ||
| - | [[2nr8]] – hKIF9+ADP<br /> | ||
[[2g1l]] - hKIF1C FHA domain<br /> | [[2g1l]] - hKIF1C FHA domain<br /> | ||
[[2owm]] – NcKIF1C MD – ''Neurospora crassa''<br /> | [[2owm]] – NcKIF1C MD – ''Neurospora crassa''<br /> | ||
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[[2v14]] – hKIF16B<br /> | [[2v14]] – hKIF16B<br /> | ||
[[2heh]] – hKIF2C<br /> | [[2heh]] – hKIF2C<br /> | ||
| - | [[2h58]] – hKIFC3+ADP<br /> | ||
| - | [[2gry]] – hKIF2+ADP<br /> | ||
[[2cow]] – hKIF13B CAP-gly domain – NMR<br /> | [[2cow]] – hKIF13B CAP-gly domain – NMR<br /> | ||
| - | [[1mkj]] – hKIF MD+docked FNL<br /> | ||
[[1bg2]] – hKIF MD<br /> | [[1bg2]] – hKIF MD<br /> | ||
[[3kin]], [[2kin]] – rKIF MD - rat<br /> | [[3kin]], [[2kin]] – rKIF MD - rat<br /> | ||
| - | [[2hfx]] – pKIF1A head+AMPPNP – pig<br /> | ||
| - | [[2hxh]] - pKIF1A head+ADP<br /> | ||
[[1ry6]] – KIF MD – ''Plasmodium falciparum''<br /> | [[1ry6]] – KIF MD – ''Plasmodium falciparum''<br /> | ||
[[2ncd]], [[1cz7]] – DmKIF MD non-claret disjuctional (NCD) dimer – ''Drosophila melanogaster'' <br /> | [[2ncd]], [[1cz7]] – DmKIF MD non-claret disjuctional (NCD) dimer – ''Drosophila melanogaster'' <br /> | ||
| - | [[1n6m]] – DmKIF MD+FNL<br /> | ||
[[2y5w]], [[2y65]] - DmKIF MD<br /> | [[2y5w]], [[2y65]] - DmKIF MD<br /> | ||
| + | |||
| + | ''Kinesin heavy chain complex with nucleotide'' | ||
| + | |||
| + | [[3gbj]] – hKIF13B MD+ADP – human<br /> | ||
| + | [[1vfv]], [[1vfw]] – mKIF1A MD+Mg-AMPPNP<br /> | ||
| + | [[1vfx]] - mKIF1A MD+ADP-Mg-AlFx<br /> | ||
| + | [[1vfz]] - mKIF1A MD+ADP-Mg-VO4<br /> | ||
| + | [[1v8j]] – mKIF2C MD+Mg-ADP<br /> | ||
| + | [[1i5s]] - mKIF2C MD (mutant)+Mg-ADP<br /> | ||
| + | [[1i6i]] - mKIF2C MD (mutant)+Mg-AMPPCP<br /> | ||
| + | [[1v8k]] - mKIF2C MD+Mg-AMPPNP<br /> | ||
| + | [[2cjo]] – hKIF13+inhibitor 30<br /> | ||
| + | [[2nr8]] – hKIF9+ADP<br /> | ||
| + | [[2h58]] – hKIFC3+ADP<br /> | ||
| + | [[2gry]] – hKIF2+ADP<br /> | ||
| + | [[2hfx]] – pKIF1A head+AMPPNP – pig<br /> | ||
| + | [[2hxh]] - pKIF1A head+ADP<br /> | ||
| + | |||
| + | ''Kinesin heavy chain complex with protein'' | ||
| + | |||
| + | [[2wbe]] – cKIF MD+FNL+Tubulin A+Tubulin B+AMPPNP – cow <br /> | ||
| + | [[1ia0]] – KIF1A MD+Tubulin A+Tubulin B+ATP - pig<br /> | ||
| + | [[3edl]] – cKIF MD+ Tubulin A+Tubulin B – EM<br /> | ||
| + | [[4hna]] – hKIF1 + Tubulin A + Tubulin B + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br /> | ||
| + | [[2p4n]] – hKIF+ Tubulin A+Tubulin B – EM docking<br /> | ||
| + | [[1mkj]] – hKIF MD+docked FNL<br /> | ||
| + | [[1n6m]] – DmKIF MD+FNL<br /> | ||
[[4atx]] - rKIF MD+ Tubulin A+Tubulin B – EM | [[4atx]] - rKIF MD+ Tubulin A+Tubulin B – EM | ||
Revision as of 07:08, 7 October 2013
3D Structure of Kinesin
The image at the left is a Crystal Structure of the Kif1A Motor Domain Before Mg Release (2zfi)
Contents |
Kinesin
Kinesins are eukaryotic motor proteins which move along microtubules. Kinesin (KIF) is a dimer consisting of 2 heavy chains and two light chains. The heavy chain contains the globular motor domain (MD), flexible neck linker (FNL) and a long coiled-coil stalk which intertwines to form the dimer. The light chain (KLC) forms the tail region. The KLC contains a cargo binding domain which is called TPR (Tetratricopeptide repeat). The KIFs are named by their gene number. KIF contains a forkhead-associated domain (FHA) which is involved in phosphopeptide recognition. Kinesin protein in yeast is called Kar3. Eg5 or KIF11 is a kinesin (Kinesin-5) which participates in mitosis. KCBP is a Kinesin-like Calmodulin Binding Protein. NOD is a Drosophila chromosome-associated kinesin.
3D Structures of Kinesin
Updated on 07-October-2013
Kinesin heavy chain (KIF)
2zfi, 2zfj, 2zfk, 2zfl, 2zfm – mKIF1A – mouse
2vvg – KIF2 MD – Giardia intestinalis
2g1l - hKIF1C FHA domain
2owm – NcKIF1C MD – Neurospora crassa
1goj – NcKIF MD
3bfn – hKIF22 MD
3b6u, 3b6v – hKIF3B MD
2rep – hKIFC1 MD
2eh0 - hKIF1B FHA domain – NMR
2edu – hKIF22 C-terminal – NMR
2v14 – hKIF16B
2heh – hKIF2C
2cow – hKIF13B CAP-gly domain – NMR
1bg2 – hKIF MD
3kin, 2kin – rKIF MD - rat
1ry6 – KIF MD – Plasmodium falciparum
2ncd, 1cz7 – DmKIF MD non-claret disjuctional (NCD) dimer – Drosophila melanogaster
2y5w, 2y65 - DmKIF MD
Kinesin heavy chain complex with nucleotide
3gbj – hKIF13B MD+ADP – human
1vfv, 1vfw – mKIF1A MD+Mg-AMPPNP
1vfx - mKIF1A MD+ADP-Mg-AlFx
1vfz - mKIF1A MD+ADP-Mg-VO4
1v8j – mKIF2C MD+Mg-ADP
1i5s - mKIF2C MD (mutant)+Mg-ADP
1i6i - mKIF2C MD (mutant)+Mg-AMPPCP
1v8k - mKIF2C MD+Mg-AMPPNP
2cjo – hKIF13+inhibitor 30
2nr8 – hKIF9+ADP
2h58 – hKIFC3+ADP
2gry – hKIF2+ADP
2hfx – pKIF1A head+AMPPNP – pig
2hxh - pKIF1A head+ADP
Kinesin heavy chain complex with protein
2wbe – cKIF MD+FNL+Tubulin A+Tubulin B+AMPPNP – cow
1ia0 – KIF1A MD+Tubulin A+Tubulin B+ATP - pig
3edl – cKIF MD+ Tubulin A+Tubulin B – EM
4hna – hKIF1 + Tubulin A + Tubulin B + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4
2p4n – hKIF+ Tubulin A+Tubulin B – EM docking
1mkj – hKIF MD+docked FNL
1n6m – DmKIF MD+FNL
4atx - rKIF MD+ Tubulin A+Tubulin B – EM
Kinesin light chain (KLC)
3edt – hKLC2
3ceq, 3nf1 – hKLC2 TPR domain
Kinesin-14
1f9t, 1f9u, 1f9v, 1f9w, 3kar - Kar3 MD (mutant) - yeast
3l1c – DmNCD (mutant)
Eg5
3ken - hKIF11 MD+S-trityl-L-cysteine
2q2y, 2fky, 2q2z, 2g1q, 2fl2, 2fl6, 1yrs - hKIF11+inhibitors
2pg2 - hKIF11+inhibitor 15+ADP
2uyi - hKIF11+inhibitor 33+ADP
2uym - hKIF11+inhibitor 37+ADP
2ieh - hKIF11+inhibitor (R)-mon97
2fme, 3l9h - hKIF11+quinoline inhibitor
1x88, 1q0b - hKIF11 MD+MgADP+monastrol
3k3b - hKIF11 MD+tetrahydro-beta-carboline
3hqd - hKIF11 MD+AMPPNP+Mg
1ii6 - hKIF11 MD+ADP+Mg
3k5e - hKIF11 MD+ADP+enastrol
KCBP
3h4s – KCBP+ADP+Mg – Arabidopsis thaliana
NOD
3dc4 – DmNOD catalytic core domain+ADP
3dcb - DmNOD catalytic core domain+AMPPNP
3dco - DmNOD catalytic core domain+ cTubulin A+cTubulin B
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman, Jaime Prilusky
