4kfq

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'''Unreleased structure'''
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{{STRUCTURE_4kfq| PDB=4kfq | SCENE= }}
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===Crystal structure of the NMDA receptor GluN1 ligand binding domain in complex with 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one===
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{{ABSTRACT_PUBMED_12805203}}
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The entry 4kfq is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref>
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Authors: Steffensen, T.B, Tabrizi, F.M., Gajhede, M, Kastrup, J.S
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==About this Structure==
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[[4kfq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFQ OCA].
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Description: Crystal structure of the NMDA receptor GluN1 ligand binding domain in complex with 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one
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==Reference==
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<ref group="xtra">PMID:012805203</ref><references group="xtra"/><references/>
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[[Category: Rattus norvegicus]]
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[[Category: Gajhede, M]]
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[[Category: Kastrup, J S]]
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[[Category: Steffensen, T B]]
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[[Category: Tabrizi, F M.]]
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[[Category: Ionotropic glutamate receptor]]
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[[Category: Ligand binding domain]]
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[[Category: Membrane protein]]

Revision as of 06:29, 10 October 2013

Template:STRUCTURE 4kfq

Contents

Crystal structure of the NMDA receptor GluN1 ligand binding domain in complex with 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one

Template:ABSTRACT PUBMED 12805203

Function

[NMDZ1_RAT] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.[1]

About this Structure

4kfq is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Furukawa H, Gouaux E. Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core. EMBO J. 2003 Jun 16;22(12):2873-85. PMID:12805203 doi:10.1093/emboj/cdg303
  1. ↑ Inanobe A, Furukawa H, Gouaux E. Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron. 2005 Jul 7;47(1):71-84. PMID:15996549 doi:10.1016/j.neuron.2005.05.022

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