Response regulator

From Proteopedia

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Revision as of 08:41, 13 October 2013

Response regulators (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal shich is the signal receiving domain and C terminal which is the DNA-binding domain. RR CheY is a chemotaxis response regulator in bacteria. RR Spo0 is the sporulation response regulator. For details see:
For PleD:

For PhoP:

For photosynthetic apparatus RR:

PrrA in Rhodobacter sphaeroides

For WspR RR:

WspR.

3D Structures of response regulator

Updated on 13-October-2013

Nitrate/nitrite RR

1rnl, 1a04 – EcNarL – Escherichia coli
1je8, 1zg1, 1zg5 – EcNarL DNA-binding domain + DNA

Sporulation RR

1srr, 2jvi, 2jvj, 2jvk – BsSpo0F (mutant) – Bacillus subtilis
1nat - BsSpo0F
3q15 - BsSpo0F + RR aspartate phosphatase
1ixm - BsSpo0B
1fc3 – GsSpo0A trans-activation domain – Geobacillus stearothermophilus
1dz3, 1qmp - GsSpo0A reciever domain

DNA-binding RR

1kgs – TmDrrD – Thermotoga maritima
3nnn – TmDrrD receiver domain + BeF3
1p2f – TmDrrB
3nns - TmDrrB receiver domain + BeF3
1nxo, 1nxp, 1nxs, 1nxt, 1nxv, 1nxw, 1nxx – SpMicArec receiver domain – Streptococcus pneumonia
2gwr - MtMtrA – Mycobacterium tuberculosis
2hwv – VicR C terminal – Enterococcus faecalis
2qsj – LuxR – Silicibbacter pomeroyi
3cnb, 3eqz – MerR receiver domain – Colwellia psychrerythraea
2rnj – SaVraR DNA-binding domain – Staphylococcus aureus – NMR
2zxj - SaWalR DNA-binding domain
4gvp – SaVraR
4if4 – SaVraR + Mg + BeF3
3q9s – DrRR receiver domain – Deinococcus radiodurans
3q9v - DrRR C terminal
3rjp - RR DNA -binding domain – Streptococcus pyogenes

Cyanobacterial phytochrome RR

1i3c – SyRcp1 – Synechocystis
1jlk – SyRcp1 + Mn
1k66 – ToRcpB – Tolypothrix
1k68 – ToRcpB

Phosphatase synthesis RR

1mvo – BsPhoP receiver domain
2jb9, 2jba – EcPhoB (mutant)
2pmu – MtPhoP DNA-binding domain

Polar differentiation RR

1m5t, 1m5u – CvDivK – Caulobacter vibrioides
1mav, 1mb0, 1mb3 – CvDivK + cation

Photosynthetic apparatus RR

1umq – PrrA DNA-binding domain – Rhodobacter sphaeroides – NMR
1ys6 – MtPrrA
1ys7 – MtPrrA + Mg

Redox RR

1xhe – EcArcA receiver domain
1xhf – EcArcA receiver domain + BeF3

Social motility RR

2gkg, 2i6f – MxFrzS receiver domain – Myxococcus xanthus
2nt3, 2nt4 - MxFrzS receiver domain (mutant)

Stalked-cell differentiation RR

2v0n – CvPleD + GMP + GTP
2wb4, 1w25 - CvPleD + GMP

Hypoxic RR

3c3w, 1zlj – MtDosR
3c57 – MtDosR C terminal
1zlk – MtDosR C terminal + DNA

Transcriptional RR

2zwm – BsYycF receiver domain
3ulq – BsComA DNA-binding domain + RR aspartate phosphatase
2pkx – EcPhoP regulatory domain

Stress RR

3n0r – CVPhyR

Chemotaxis RR

3t8y - EcCheB
1mih, 1jbe – EcCheY
1p6q – SmCheY2 - Sinorhizobium meliloti
1p6u – SmCheY2 + BeF3
3hzh – CheY-3 + CheX – Borrelia burgdorferi
1u0s – TmCheY + CheA
2chy – CheY – Salmonella typhimurium

CheY-like RR

3snk – RR – Mesorhizobium loti
3cg4, 3crn - RR receiver domain – Methanospirillum hungatei
3i42 – RR receiver domain – Methylobacter flagellates
3bre – PaRR – Pseudomonas aeruginosa

Two-component RR

2lpm – SmRR

Unspecified RR receiver domain

2a9o, 2a9p, 2a9q – SpRR + Mn + BeF3
2a9r – SpRR + phosphate + Mg
2pln – HP1043 – Helicobacter pylori
2qr3 – RR – Bacteroides fragilis
2qxy – TmRR
2qzj – RR – Clostridium difficile
3kht – RR – Hahella chejuensis
3c3m – RR – Methanoculleus marisnigri
3cz5 – RR – Aurantimonas
3heb - RR – Rhodospirillum rubrum
3lte – RR – Bermanella marisrubri
3jte, 3lua – RR – Clostridium thermocellum
4e7o – SpRR
4e7p – SpRR + BeF3
2b4a – RR Bh3024 – Bacillus halodurans

Unspecified RR

1yio, 1zn2 – StyR – Pseudomonas fluorescens
3a0u, 3a10 – TmTrrA + Mg + BeF3
2qvg – RR – Legionella pneumophila
3gl9 - TmRR
4hye – SpRR
2zay – RR – Desulfuromonas acetoxidans
2rdm – RR (mutant) – Sinorhizobium medicae
3hdv – RR – Pseudomonas putida
3i5a – PsWspR – Pseudomonas syringae
3ilh – RR – Cytophaga hutchinsonii
3i5b – PaWspR GGDEF domain
3i5c – PaWspR GGDEF domain/GCN4 leucine zipper
3ljx – McMmoQ – Methylococcus capsulatus
3p3q – McMmoQ (mutant)
3lsg – RR C terminal – Fusobacterium nucleatum
3nhm – MxRR
3m6m – XcRpfC REC domain + enoyl-CoA hydratase – Xanthomonas campestris
3qyy – XcRR GGDEF domain + GMP
3p01 – RR residues 134-315 – Nostoc
3rqi – RR + phosphate + Ca + citrate – Burkholderia pseudomallei
3kto – RR - Pseudoalteromonas atlantica
3t0y – CvRR anti-anti-σ domain + anti-σ factor NEPR
2oqr – MtRR Regx3
3sy8 – PaRR Rocr

RR complex with histidine kinase

3dge, 3dgf – TmRR + sensor protein
3a0r – TmTrrA (mutant) + sensor protein

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Response_regulator"

Category: Topic Page

@@ Line 21: / Line 21: @@
 == 3D Structures of response regulator ==
-''Updated February 2013''
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 ===Nitrate/nitrite RR===
@@ Line 30: / Line 30: @@
 ===Sporulation RR===
-[[1srr]] – BsSpo0F (mutant) – ''Bacillus subtilis''<br/ >
+[[1srr]], [[2jvi]], [[2jvj]], [[2jvk]] – BsSpo0F (mutant) – ''Bacillus subtilis''<br/ >
 [[1nat]] - BsSpo0F<br/ >
 [[3q15]] - BsSpo0F + RR aspartate phosphatase<br/ >
 [[1ixm]] - BsSpo0B<br/ >
 [[1fc3]] – GsSpo0A trans-activation domain – ''Geobacillus stearothermophilus''<br />
-[[1dz3]] - GsSpo0A reciever domain
+[[1dz3]], [[1qmp]] - GsSpo0A reciever domain
 ===DNA-binding RR===
@@ Line 47: / Line 47: @@
 [[2hwv]] – VicR C terminal – ''Enterococcus faecalis''<br/ >
 [[2qsj]] – LuxR – ''Silicibbacter pomeroyi''<br/ >
-[[3cnb]], 3eqz]] – MerR receiver domain – ''Colwellia psychrerythraea''<br/ >
+[[3cnb]], [[3eqz]] – MerR receiver domain – ''Colwellia psychrerythraea''<br/ >
 [[2rnj]] – SaVraR DNA-binding domain – ''Staphylococcus aureus'' – NMR<br/ >
 [[2zxj]] - SaWalR DNA-binding domain<br/ >
+[[4gvp]] – SaVraR<br />
+[[4if4]] – SaVraR + Mg + BeF3<br />
 [[3q9s]] – DrRR receiver domain – ''Deinococcus radiodurans''<br/ >
-[[3q9v]] - DrRR C terminal
+[[3q9v]] - DrRR C terminal<br />
+[[3rjp]] - RR DNA -binding domain – ''Streptococcus pyogenes''<br />
 ===Cyanobacterial phytochrome RR===
@@ Line 94: / Line 97: @@
 ===Hypoxic RR===
-[[3c3w]] – MtDosR<br/ >
+[[3c3w]], [[1zlj]] – MtDosR<br/ >
-[[3c57]] – MtDosR C terminal
+[[3c57]] – MtDosR C terminal<br />
+[[1zlk]] – MtDosR C terminal + DNA<br />
 ===Transcriptional RR===
@@ Line 110: / Line 114: @@
 [[3t8y]] - EcCheB<br />
-[[1mih]] – EcCheY<br />
+[[1mih]], [[1jbe]] – EcCheY<br />
 [[1p6q]] – SmCheY2 - ''Sinorhizobium meliloti''<br />
 [[1p6u]] – SmCheY2 + BeF3<br />
 [[3hzh]] – CheY-3 + CheX – ''Borrelia burgdorferi''<br />
 [[1u0s]] – TmCheY + CheA<br />
-[[2chy]] – Chey – ''Salmonella typhimurium''
+[[2chy]] – CheY – ''Salmonella typhimurium''
 ===CheY-like RR===
@@ Line 143: / Line 147: @@
 [[3jte]], [[3lua]] – RR – ''Clostridium thermocellum''<br />
 [[4e7o]] – SpRR<br />
-[[4e7p]] – SpRR + BeF3
+[[4e7p]] – SpRR + BeF3<br />
+[[2b4a]] – RR Bh3024 – ''Bacillus halodurans''<br />
 ===Unspecified RR===
@@ Line 151: / Line 156: @@
 [[2qvg]] – RR – ''Legionella pneumophila''<br/ >
 [[3gl9]] - TmRR<br/ >
+[[4hye]] – SpRR<br />
 [[2zay]] – RR – ''Desulfuromonas acetoxidans''<br/ >
 [[2rdm]] – RR (mutant) – ''Sinorhizobium medicae''<br/ >
@@ Line 167: / Line 173: @@
 [[3rqi]] – RR + phosphate + Ca + citrate – ''Burkholderia pseudomallei''<br/ >
 [[3kto]] – RR - ''Pseudoalteromonas atlantica''<br />
-[[3t0y]] – CvRR anti-anti-σ domain + anti-σ factor NEPR
+[[3t0y]] – CvRR anti-anti-σ domain + anti-σ factor NEPR<br />
+[[2oqr]] – MtRR Regx3 <br />
+[[3sy8]] – PaRR Rocr <br />
 ===RR complex with histidine kinase===
-[[3dge]], 3dgf]] – TmRR + sensor protein<br/ >
+[[3dge]], [[3dgf]] – TmRR + sensor protein<br/ >
 [[3a0r]] – TmTrrA (mutant) + sensor protein