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Ribonucleotide reductase

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{{STRUCTURE_1xjf| PDB=1xjf | SIZE=400| SCENE= |right|CAPTION=Ribonucleotide reductase dimer complex with DTP and Mg+2 ion, [[1xjf]] }}
{{STRUCTURE_1xjf| PDB=1xjf | SIZE=400| SCENE= |right|CAPTION=Ribonucleotide reductase dimer complex with DTP and Mg+2 ion, [[1xjf]] }}
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'''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. The RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Thymidine triphosphate (TTP) is an effector in the reaction. For details on human RNR2 see [[P53R2]]. For mouse RNR see [[Mouse Ribonucleotide Reductase R2]].
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'''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR. Class I RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction. Class II RNR reduces ribonucleotide triphosphates using coenzyme B12. Class III RNR generate glycine radical using S-adenosyl methionine and Fe-S center. For details on human RNR2 see [[P53R2]]. For mouse RNR see [[Mouse Ribonucleotide Reductase R2]].
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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==Class I RNR==
===RNR large subunit===
===RNR large subunit===
[[1zyz]], [[1zzd]], [[2cvs]], [[2cvt]], [[2cvu]], [[2cvv]], [[2cvw]], [[2cvx]], [[2cvy]] - yRNR R1 – yeast<BR />
[[1zyz]], [[1zzd]], [[2cvs]], [[2cvt]], [[2cvu]], [[2cvv]], [[2cvw]], [[2cvx]], [[2cvy]] - yRNR R1 – yeast<BR />
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[[1pem]] - StRNR R1 - ''Salmonella typhimurium''<BR />
 
[[5r1r]], [[6r1r]], [[7r1r]], [[1r1r]], [[1rlr]], [[1mrr]] - EcRNR R1 – ''Escherichia coli''
[[5r1r]], [[6r1r]], [[7r1r]], [[1r1r]], [[1rlr]], [[1mrr]] - EcRNR R1 – ''Escherichia coli''
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[[2eud]] - yRNR R1 + ligand<BR />
[[2eud]] - yRNR R1 + ligand<BR />
[[3rsr]] – yRNR + inhibitor<br />
[[3rsr]] – yRNR + inhibitor<br />
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[[1peo]], [[1peq]], [[2peu]] - StRNR R1 + effector<BR />
 
[[2r1r]] - EcRNR R1 + TTP<BR />
[[2r1r]] - EcRNR R1 + TTP<BR />
[[3r1r]] - EcRNR R1 + AMPPNP<BR />
[[3r1r]] - EcRNR R1 + AMPPNP<BR />
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[[4dr0]] - RNR + Mn – Bacillus subtilis<br />
[[4dr0]] - RNR + Mn – Bacillus subtilis<br />
[[1uzr]] – RNR R2 – ''Mycobacterium tuberculosis''<BR />
[[1uzr]] – RNR R2 – ''Mycobacterium tuberculosis''<BR />
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[[1r2f]] - StRNR R2<br />
 
[[3olj]] – hRNR M2<br />
[[3olj]] – hRNR M2<br />
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[[1jk0]] – yRNR Y2+Y4<br />
[[3vpm]], [[3vpn]], [[3vpo]] – hRNR M2 (mutant)<br />
[[3vpm]], [[3vpn]], [[3vpo]] – hRNR M2 (mutant)<br />
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[[2xav]], [[2xaw]], [[2xax]], [[2xay]], [[2xaz]], [[2x0x]] - EcRNR R1 (mutant) + R2 peptide<BR />
[[2xav]], [[2xaw]], [[2xax]], [[2xay]], [[2xaz]], [[2x0x]] - EcRNR R1 (mutant) + R2 peptide<BR />
[[2bq1]] - StRNR R1+ R2
[[2bq1]] - StRNR R1+ R2
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==Class II RNR==
[[1xjf]] – TmRNR + ATP – ''Thermotoga maritima''<BR />
[[1xjf]] – TmRNR + ATP – ''Thermotoga maritima''<BR />
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[[1xjm]] - TmRNR + TTP<BR />
[[1xjm]] - TmRNR + TTP<BR />
[[1xje]] - TmRNR + TTP-GDP<BR />
[[1xje]] - TmRNR + TTP-GDP<BR />
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[[1xjn]] - TmRNR + ATP-CDP
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[[1xjn]] - TmRNR + ATP-CDP<br />
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[[1pem]] - StRNR R1 - ''Salmonella typhimurium''<BR />
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[[1peo]], [[1peq]], [[2peu]] - StRNR R1 + effector<BR />
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[[1l1l]] – RNR (mutant) – ''Lactobacillus leichmannii''<br />
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==Class III RNR==
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[[1h78]], [[1h79]], [[1h7a]], [[1hk8]] – T4RNR (mutant) + nucleotide triphosphate – bacteriophage T4<br />
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[[1h7b]] – T4RNR (mutant) <br />

Revision as of 08:56, 14 October 2013

Template:STRUCTURE 1xjf

Ribonucleotide reductase (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR. Class I RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction. Class II RNR reduces ribonucleotide triphosphates using coenzyme B12. Class III RNR generate glycine radical using S-adenosyl methionine and Fe-S center. For details on human RNR2 see P53R2. For mouse RNR see Mouse Ribonucleotide Reductase R2.

Contents

3D Structures of Ribonucleotide reductase

Updated on 14-October-2013

Class I RNR

RNR large subunit

1zyz, 1zzd, 2cvs, 2cvt, 2cvu, 2cvv, 2cvw, 2cvx, 2cvy - yRNR R1 – yeast
5r1r, 6r1r, 7r1r, 1r1r, 1rlr, 1mrr - EcRNR R1 – Escherichia coli

RNR large subunit complex

3hnc – hRNR M1 + TTP – human
3hnd – hRNR M1 + GDP + TTP
3hne, 3hnf – hRNR M1 + ATP + TTP
2wgh - hRNR M1 + ATP + Mg
3paw - yRNR R1 + ATP
3k8t - yRNR R1 + ADP analog
3s87 - yRNR R1 + ADP + GTP
3s8a - yRNR R1 (mutant) + GTP
3tba - yRNR R1 (mutant) + GTP + ADP
3s8b - yRNR R1 + AMPPNP + CDP
3s8c, 3tb9 - yRNR R1 (mutant) + AMPPNP + CDP
2zlf, 2zlg - yRNR R1 + peptide
2eud - yRNR R1 + ligand
3rsr – yRNR + inhibitor
2r1r - EcRNR R1 + TTP
3r1r - EcRNR R1 + AMPPNP
4r1r - EcRNR R1 + GDP + TTP

RNR small subunit

2xof, 3n37, 3n38, 2alx, 1piy, 1r65, 1mxr, 1jqc, 1jpr, 1av8, 1xik, 1rib – EcRNR R2
1yfd, 1piz, 1pj0, 1pj1, 1pm2, 1pim, 1piu, 1biq, 2av8, 1pfr - EcRNR R2 (mutant)
3hf1, 2vux, 2uw2 – hRNR M2
3mjo, 3dhz, 1oqu, 1kgn, 1kgo, 1kgp – RNR R2 – Corynebacterium ammoniagenes
2p1i – RNR R2 – Plasmodium yoelii
2o1z - RNR R2 – Plasmodium vivax
1w68, 1h0n, 1h0o, 1xsm – mRNR R2 – mouse
1smq, 1sms – yRNR 2
4d8f, 4d8g - CtRNR R2 + Fe + Mn
1syy - CtRNR R2 + Fe + Pb– Chlamydia trachomatis
2ani - CtRNR R2 (mutant) + Fe + Pb
4dr0 - RNR + Mn – Bacillus subtilis
1uzr – RNR R2 – Mycobacterium tuberculosis
3olj – hRNR M2
1jk0 – yRNR Y2+Y4
3vpm, 3vpn, 3vpo – hRNR M2 (mutant)

RNR small subunit complex

1rsr, 1rsv - EcRNR R2 (mutant) + N3
3n39, 3n3a, 3n3b – EcRNR R2 + NrdI
1rnr – EcRNR R2 (mutant) + dopa
1w69 – mRNR R2 + acetate

RNR small+large subunit

3uus, 4erm - EcRNR R1+ R2
4erp - EcRNR R1+ R2 + inhibitor
2xak, 2xap, 2xo4, 2xo5 - EcRNR R1+ R2 peptide
2xav, 2xaw, 2xax, 2xay, 2xaz, 2x0x - EcRNR R1 (mutant) + R2 peptide
2bq1 - StRNR R1+ R2

Class II RNR

1xjf – TmRNR + ATP – Thermotoga maritima
1xjg - TmRNR + ATP-UDP
1xjj - TmRNR + GTP
1xjk - TmRNR + GTP-ADP
1xjm - TmRNR + TTP
1xje - TmRNR + TTP-GDP
1xjn - TmRNR + ATP-CDP
1pem - StRNR R1 - Salmonella typhimurium
1peo, 1peq, 2peu - StRNR R1 + effector
1l1l – RNR (mutant) – Lactobacillus leichmannii

Class III RNR

1h78, 1h79, 1h7a, 1hk8 – T4RNR (mutant) + nucleotide triphosphate – bacteriophage T4
1h7b – T4RNR (mutant)

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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