2rsg

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[[Image:2rsg.jpg|left|200px]]
 
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{{STRUCTURE_2rsg| PDB=2rsg | SCENE= }}
{{STRUCTURE_2rsg| PDB=2rsg | SCENE= }}
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===Solution structure of the CERT PH domain===
===Solution structure of the CERT PH domain===
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{{ABSTRACT_PUBMED_22869376}}
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==Function==
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[[http://www.uniprot.org/uniprot/C43BP_HUMAN C43BP_HUMAN]] Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.<ref>PMID:14685229</ref> <ref>PMID:17591919</ref> <ref>PMID:18184806</ref> <ref>PMID:20036255</ref>
==About this Structure==
==About this Structure==
[[2rsg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RSG OCA].
[[2rsg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RSG OCA].
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==Reference==
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<ref group="xtra">PMID:022869376</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hanada, K.]]
[[Category: Hanada, K.]]

Revision as of 06:45, 16 October 2013

Template:STRUCTURE 2rsg

Contents

Solution structure of the CERT PH domain

Template:ABSTRACT PUBMED 22869376

Function

[C43BP_HUMAN] Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.[1] [2] [3] [4]

About this Structure

2rsg is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Sugiki T, Takeuchi K, Yamaji T, Takano T, Tokunaga Y, Kumagai K, Hanada K, Takahashi H, Shimada I. Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT). J Biol Chem. 2012 Sep 28;287(40):33706-18. Epub 2012 Aug 6. PMID:22869376 doi:http://dx.doi.org/10.1074/jbc.M112.367730
  1. ↑ Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M. Molecular machinery for non-vesicular trafficking of ceramide. Nature. 2003 Dec 18;426(6968):803-9. PMID:14685229 doi:http://dx.doi.org/10.1038/nature02188
  2. ↑ Fugmann T, Hausser A, Schoffler P, Schmid S, Pfizenmaier K, Olayioye MA. Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein. J Cell Biol. 2007 Jul 2;178(1):15-22. Epub 2007 Jun 25. PMID:17591919 doi:http://dx.doi.org/jcb.200612017
  3. ↑ Kudo N, Kumagai K, Tomishige N, Yamaji T, Wakatsuki S, Nishijima M, Hanada K, Kato R. Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):488-93. Epub 2008 Jan 9. PMID:18184806
  4. ↑ Kudo N, Kumagai K, Matsubara R, Kobayashi S, Hanada K, Wakatsuki S, Kato R. Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer. J Mol Biol. 2010 Feb 19;396(2):245-51. Epub 2009 Dec 28. PMID:20036255 doi:10.1016/j.jmb.2009.12.029

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