4je3

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'''Unreleased structure'''
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{{STRUCTURE_4je3| PDB=4je3 | SCENE= }}
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===An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation===
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{{ABSTRACT_PUBMED_24075991}}
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The entry 4je3 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/IML3_YEAST IML3_YEAST]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.<ref>PMID:11361335</ref> <ref>PMID:15241623</ref> [[http://www.uniprot.org/uniprot/CHL4_YEAST CHL4_YEAST]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.<ref>PMID:9339342</ref>
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Authors: Hinshaw, S.M., Harrison, S.C.
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==About this Structure==
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[[4je3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JE3 OCA].
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Description: An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation
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==Reference==
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<ref group="xtra">PMID:024075991</ref><references group="xtra"/><references/>
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Harrison, S C.]]
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[[Category: Hinshaw, S M.]]
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[[Category: Beta sheet]]
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[[Category: Cell cycle]]
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[[Category: Chromosome segregation]]
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[[Category: Iml3-chl4 dimer]]
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[[Category: Kinetochore]]
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[[Category: Nucleus]]

Revision as of 08:00, 16 October 2013

Template:STRUCTURE 4je3

Contents

An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation

Template:ABSTRACT PUBMED 24075991

Function

[IML3_YEAST] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.[1] [2] [CHL4_YEAST] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.[3]

About this Structure

4je3 is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Hinshaw SM, Harrison SC. An Iml3-Chl4 Heterodimer Links the Core Centromere to Factors Required for Accurate Chromosome Segregation. Cell Rep. 2013 Sep 25. pii: S2211-1247(13)00477-4. doi:, 10.1016/j.celrep.2013.08.036. PMID:24075991 doi:http://dx.doi.org/10.1016/j.celrep.2013.08.036
  1. ↑ Ghosh SK, Poddar A, Hajra S, Sanyal K, Sinha P. The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation. Mol Genet Genomics. 2001 Apr;265(2):249-57. PMID:11361335
  2. ↑ Ghosh SK, Sau S, Lahiri S, Lohia A, Sinha P. The Iml3 protein of the budding yeast is required for the prevention of precocious sister chromatid separation in meiosis I and for sister chromatid disjunction in meiosis II. Curr Genet. 2004 Aug;46(2):82-91. Epub 2004 Jul 6. PMID:15241623 doi:http://dx.doi.org/10.1007/s00294-004-0516-6
  3. ↑ Roy N, Poddar A, Lohia A, Sinha P. The mcm17 mutation of yeast shows a size-dependent segregational defect of a mini-chromosome. Curr Genet. 1997 Sep;32(3):182-9. PMID:9339342

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