4mh5

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'''Unreleased structure'''
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{{STRUCTURE_4mh5| PDB=4mh5 | SCENE= }}
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===Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-glutamate===
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{{ABSTRACT_PUBMED_21907808}}
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The entry 4mh5 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/GRIK3_RAT GRIK3_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.<ref>PMID:21907808</ref>
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Authors: Venskutonyte, R., Frydenvang, K., Gajhede, M., Kastrup, J.S.
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==About this Structure==
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[[4mh5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MH5 OCA].
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Description: Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-glutamate
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==Reference==
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<ref group="xtra">PMID:021907808</ref><references group="xtra"/><references/>
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[[Category: Rattus norvegicus]]
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[[Category: Frydenvang, K.]]
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[[Category: Gajhede, M.]]
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[[Category: Kastrup, J S.]]
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[[Category: Venskutonyte, R.]]
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[[Category: Agonist]]
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[[Category: Membrane]]
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[[Category: Receptor]]
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[[Category: Receptor-agonist complex]]

Revision as of 08:01, 16 October 2013

Template:STRUCTURE 4mh5

Contents

Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-glutamate

Template:ABSTRACT PUBMED 21907808

Function

[GRIK3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.[1]

About this Structure

4mh5 is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Venskutonyte R, Frydenvang K, Gajhede M, Bunch L, Pickering DS, Kastrup JS. Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. J Struct Biol. 2011 Sep 1. PMID:21907808 doi:10.1016/j.jsb.2011.08.014
  1. ↑ Venskutonyte R, Frydenvang K, Gajhede M, Bunch L, Pickering DS, Kastrup JS. Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. J Struct Biol. 2011 Sep 1. PMID:21907808 doi:10.1016/j.jsb.2011.08.014

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