4bbx

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m (Protected "4bbx" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4bbx| PDB=4bbx | SCENE= }}
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===Discovery of a potent, selective and orally active PDE10A inhibitor for the treatment of schizophrenia===
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The entry 4bbx is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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Authors: Bartolome-Nebreda, J.M., Conde-Ceide, S., Delgado, F., Martin, M.L., Martinez-Viturro, C.M., Pastor, J., Tong, H.M., Iturrino, L., Macdonald, G.J., Sanderson, W., Megens, A., Langlois, X., Somers, M., Vanhoof, G.
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==About this Structure==
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[[4bbx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBX OCA].
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Description: Discovery of a potent, selective and orally active PDE10A inhibitor for the treatment of schizophrenia
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Bartolome-Nebreda, J M.]]
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[[Category: Conde-Ceide, S.]]
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[[Category: Delgado, F.]]
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[[Category: Iturrino, L.]]
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[[Category: Langlois, X.]]
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[[Category: Macdonald, G J.]]
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[[Category: Martin, M L.]]
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[[Category: Martinez-Viturro, C M.]]
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[[Category: Megens, A.]]
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[[Category: Pastor, J.]]
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[[Category: Sanderson, W.]]
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[[Category: Somers, M.]]
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[[Category: Tong, H M.]]
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[[Category: Vanhoof, G.]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor complex]]
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[[Category: Magnesium binding]]
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[[Category: Phosphodiesterase inhibitor]]
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[[Category: Zinc binding]]

Revision as of 08:05, 16 October 2013

Template:STRUCTURE 4bbx

Contents

Discovery of a potent, selective and orally active PDE10A inhibitor for the treatment of schizophrenia

Function

[PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.[1]

About this Structure

4bbx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Structural insight into substrate specificity of phosphodiesterase 10. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5782-7. Epub 2007 Mar 26. PMID:17389385

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OCA

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