4gwt

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'''Unreleased structure'''
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{{STRUCTURE_4gwt| PDB=4gwt | SCENE= }}
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===Structure of racemic Pin1 WW domain cocrystallized with DL-malic acid===
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The entry 4gwt is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
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Authors: Mortenson, D.E., Yun, H.G., Gellman, S.H., Forest, K.T.
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==About this Structure==
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[[4gwt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWT OCA].
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Description: Structure of racemic Pin1 WW domain cocrystallized with DL-malic acid
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Forest, K T.]]
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[[Category: Gellman, S H.]]
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[[Category: Mortenson, D E.]]
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[[Category: Yun, H G.]]
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[[Category: Proline phosphoser/thr binding]]
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[[Category: Protein binding]]
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[[Category: Racemic crystallization]]
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[[Category: Ww domain]]

Revision as of 08:06, 16 October 2013

Template:STRUCTURE 4gwt

Contents

Structure of racemic Pin1 WW domain cocrystallized with DL-malic acid

Function

[PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.[1] [2] [3]

About this Structure

4gwt is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Dougherty MK, Muller J, Ritt DA, Zhou M, Zhou XZ, Copeland TD, Conrads TP, Veenstra TD, Lu KP, Morrison DK. Regulation of Raf-1 by direct feedback phosphorylation. Mol Cell. 2005 Jan 21;17(2):215-24. PMID:15664191 doi:10.1016/j.molcel.2004.11.055
  2. ↑ Yu L, Mohamed AJ, Vargas L, Berglof A, Finn G, Lu KP, Smith CI. Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1. J Biol Chem. 2006 Jun 30;281(26):18201-7. Epub 2006 Apr 27. PMID:16644721 doi:10.1074/jbc.M603090200
  3. ↑ Lee TH, Chen CH, Suizu F, Huang P, Schiene-Fischer C, Daum S, Zhang YJ, Goate A, Chen RH, Zhou XZ, Lu KP. Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function. Mol Cell. 2011 Apr 22;42(2):147-59. doi: 10.1016/j.molcel.2011.03.005. Epub 2011 , Apr 14. PMID:21497122 doi:10.1016/j.molcel.2011.03.005

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