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4m69

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'''Unreleased structure'''
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{{STRUCTURE_4m69| PDB=4m69 | SCENE= }}
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===Crystal structure of the mouse RIP3-MLKL complex===
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The entry 4m69 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/RIPK3_MOUSE RIPK3_MOUSE]] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).<ref>PMID:19590578</ref> [[http://www.uniprot.org/uniprot/MLKL_MOUSE MLKL_MOUSE]] Required for the execution of programmed necrosis (By similarity).
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Authors: Xie, T., Peng, W., Yan, C., Wu, J., Shi, Y.
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==About this Structure==
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[[4m69]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M69 OCA].
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Description: Crystal structure of the mouse RIP3-MLKL complex
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Peng, W.]]
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[[Category: Shi, Y.]]
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[[Category: Wu, J.]]
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[[Category: Xie, T.]]
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[[Category: Yan, C.]]
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[[Category: Kinase]]
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[[Category: Phosphorylation]]
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[[Category: Transferase-signaling protein complex]]

Revision as of 08:10, 16 October 2013

Template:STRUCTURE 4m69

Contents

Crystal structure of the mouse RIP3-MLKL complex

Function

[RIPK3_MOUSE] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).[1] [MLKL_MOUSE] Required for the execution of programmed necrosis (By similarity).

About this Structure

4m69 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J. DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep. 2009 Aug;10(8):916-22. doi: 10.1038/embor.2009.109. Epub 2009 Jul 10. PMID:19590578 doi:http://dx.doi.org/10.1038/embor.2009.109

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OCA

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