4mvt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4mvt" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4mvt| PDB=4mvt | SCENE= }}
 +
===Crystal structure of SUMO E3 Ligase PIAS3===
-
The entry 4mvt is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/PIAS3_HUMAN PIAS3_HUMAN]] Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth.<ref>PMID:9388184</ref>
-
Authors: Dong, A., Hu, J., Li, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
+
==About this Structure==
 +
[[4mvt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVT OCA].
-
Description: Crystal structure of SUMO E3 Ligase PIAS3
+
==Reference==
 +
<references group="xtra"/><references/>
 +
[[Category: Homo sapiens]]
 +
[[Category: Arrowsmith, C H.]]
 +
[[Category: Bountra, C.]]
 +
[[Category: Dong, A.]]
 +
[[Category: Edwards, A M.]]
 +
[[Category: Hu, J.]]
 +
[[Category: Li, Y.]]
 +
[[Category: SGC, Structural Genomics Consortium.]]
 +
[[Category: Tempel, W.]]
 +
[[Category: Tong, Y.]]
 +
[[Category: E3 ligase]]
 +
[[Category: Ligase]]
 +
[[Category: Pinit domain]]
 +
[[Category: Sgc]]
 +
[[Category: Sp-ring domain]]
 +
[[Category: Structural genomic]]
 +
[[Category: Structural genomics consortium]]
 +
[[Category: Sumo]]

Revision as of 08:12, 16 October 2013

Template:STRUCTURE 4mvt

Contents

Crystal structure of SUMO E3 Ligase PIAS3

Function

[PIAS3_HUMAN] Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth.[1]

About this Structure

4mvt is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Chung CD, Liao J, Liu B, Rao X, Jay P, Berta P, Shuai K. Specific inhibition of Stat3 signal transduction by PIAS3. Science. 1997 Dec 5;278(5344):1803-5. PMID:9388184

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4mvt"
Personal tools