1w8b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 36: Line 36:
[[Category: serine protease]]
[[Category: serine protease]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:59:19 2007''
+
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:28:08 2007''

Revision as of 14:23, 30 October 2007

Image:1w8b.gif

1w8b, resolution 3.00Å

Drag the structure with the mouse to rotate

FACTOR7- 413 COMPLEX

Overview

We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere, with the coagulation cascade by selective inhibition of the extrinsic, pathway.

About this Structure

1W8B is a [Protein complex] structure of sequences from [Homo sapiens] with CA and 413 as [ligands]. Active as [Coagulation factor VIIa], with EC number [3.4.21.21]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors., Zbinden KG, Obst-Sander U, Hilpert K, Kuhne H, Banner DW, Bohm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lave T, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. Epub 2005 Oct 4. PMID:16213138

Page seeded by OCA on Tue Oct 30 16:28:08 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1w8b"
Personal tools