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2p74
From Proteopedia
(New page: 200px<br /><applet load="2p74" size="350" color="white" frame="true" align="right" spinBox="true" caption="2p74, resolution 0.88Å" /> '''CTX-M-9 class A beta...) |
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caption="2p74, resolution 0.88Å" /> | caption="2p74, resolution 0.88Å" /> | ||
'''CTX-M-9 class A beta-lactamase apo crystal structure at 0.88 Angstrom resolution'''<br /> | '''CTX-M-9 class A beta-lactamase apo crystal structure at 0.88 Angstrom resolution'''<br /> | ||
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| - | ==Overview== | ||
| - | The apo crystal structure of CTX-M-9 beta-lactamase has been determined to, 0.88 A at pH 8.8. This unusually clear picture of proton positions and, residue interactions supports the role of Glu166 as the general base for, the controversial acylation step of class A beta-lactamase catalysis. The, ability to distinguish low-energy conformations sampled by the enzyme, allows us to link the two conformations of Lys73 to different protonation, states of Glu166. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | The | + | The acylation mechanism of CTX-M beta-lactamase at 0.88 a resolution., Chen Y, Bonnet R, Shoichet BK, J Am Chem Soc. 2007 May 2;129(17):5378-80. Epub 2007 Apr 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17408273 17408273] |
[[Category: Beta-lactamase]] | [[Category: Beta-lactamase]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
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[[Category: Bonnet, R.]] | [[Category: Bonnet, R.]] | ||
[[Category: Chen, Y.]] | [[Category: Chen, Y.]] | ||
| - | [[Category: Shoichet, B | + | [[Category: Shoichet, B K.]] |
[[Category: K]] | [[Category: K]] | ||
[[Category: PO4]] | [[Category: PO4]] | ||
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[[Category: ultra-high resolution]] | [[Category: ultra-high resolution]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:26:40 2008'' |
Revision as of 16:26, 21 February 2008
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CTX-M-9 class A beta-lactamase apo crystal structure at 0.88 Angstrom resolution
About this Structure
2P74 is a Single protein structure of sequence from Escherichia coli with and as ligands. Active as Beta-lactamase, with EC number 3.5.2.6 Full crystallographic information is available from OCA.
Reference
The acylation mechanism of CTX-M beta-lactamase at 0.88 a resolution., Chen Y, Bonnet R, Shoichet BK, J Am Chem Soc. 2007 May 2;129(17):5378-80. Epub 2007 Apr 5. PMID:17408273
Page seeded by OCA on Thu Feb 21 18:26:40 2008
Categories: Beta-lactamase | Escherichia coli | Single protein | Bonnet, R. | Chen, Y. | Shoichet, B K. | K | PO4 | Acylation | Ctx-m | Esbl | Ultra-high resolution
