2p83
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The design and synthesis of a novel series of potent BACE1 | + | The design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D. |
==About this Structure== | ==About this Structure== | ||
| Line 10: | Line 10: | ||
==Reference== | ==Reference== | ||
| - | Potent and selective isophthalamide | + | Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1., Kortum SW, Benson TE, Bienkowski MJ, Emmons TL, Prince DB, Paddock DJ, Tomasselli AG, Moon JB, LaBorde A, TenBrink RE, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3378-83. Epub 2007 Apr 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17434734 17434734] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Benson, T | + | [[Category: Benson, T E.]] |
| - | [[Category: Emmons, T | + | [[Category: Emmons, T L.]] |
| - | [[Category: Paddock, D | + | [[Category: Paddock, D J.]] |
| - | [[Category: Prince, D | + | [[Category: Prince, D B.]] |
| - | [[Category: Tomasselli, A | + | [[Category: Tomasselli, A G.]] |
[[Category: MR0]] | [[Category: MR0]] | ||
[[Category: PO4]] | [[Category: PO4]] | ||
[[Category: protein-inhibitor complex]] | [[Category: protein-inhibitor complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:26:53 2008'' |
Revision as of 16:26, 21 February 2008
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Potent and selective isophthalamide S2 hydroxyethylamine inhibitor of BACE1
Overview
The design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D.
About this Structure
2P83 is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Memapsin 2, with EC number 3.4.23.46 Full crystallographic information is available from OCA.
Reference
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1., Kortum SW, Benson TE, Bienkowski MJ, Emmons TL, Prince DB, Paddock DJ, Tomasselli AG, Moon JB, LaBorde A, TenBrink RE, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3378-83. Epub 2007 Apr 3. PMID:17434734
Page seeded by OCA on Thu Feb 21 18:26:53 2008
