3a5z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3a5z" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:3a5z.png|left|200px]]
 
- 
{{STRUCTURE_3a5z| PDB=3a5z | SCENE= }}
{{STRUCTURE_3a5z| PDB=3a5z | SCENE= }}
- 
===Crystal structure of Escherichia coli GenX in complex with elongation factor P===
===Crystal structure of Escherichia coli GenX in complex with elongation factor P===
 +
{{ABSTRACT_PUBMED_20729861}}
-
{{ABSTRACT_PUBMED_20729861}}
+
==Function==
 +
[[http://www.uniprot.org/uniprot/C3SGA2_ECOLX C3SGA2_ECOLX]] With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF-P 'Lys-34' (By similarity).[HAMAP-Rule:MF_00174] [[http://www.uniprot.org/uniprot/C3SGD7_ECOLX C3SGD7_ECOLX]] Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation (By similarity).[HAMAP-Rule:MF_00141]
==About this Structure==
==About this Structure==
Line 14: Line 13:
==Reference==
==Reference==
-
<ref group="xtra">PMID:020729861</ref><references group="xtra"/>
+
<ref group="xtra">PMID:020729861</ref><references group="xtra"/><references/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Lysine--tRNA ligase]]
[[Category: Lysine--tRNA ligase]]

Revision as of 05:09, 23 October 2013

Template:STRUCTURE 3a5z

Contents

Crystal structure of Escherichia coli GenX in complex with elongation factor P

Template:ABSTRACT PUBMED 20729861

Function

[C3SGA2_ECOLX] With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF-P 'Lys-34' (By similarity).[HAMAP-Rule:MF_00174] [C3SGD7_ECOLX] Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation (By similarity).[HAMAP-Rule:MF_00141]

About this Structure

3a5z is a 8 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

See Also

Reference

  • Yanagisawa T, Sumida T, Ishii R, Takemoto C, Yokoyama S. A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P. Nat Struct Mol Biol. 2010 Sep;17(9):1136-43. Epub 2010 Aug 22. PMID:20729861 doi:10.1038/nsmb.1889

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3a5z"
Personal tools