3wh3

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m (Protected "3wh3" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_3wh3| PDB=3wh3 | SCENE= }}
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===human Mincle, ligand free form===
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{{ABSTRACT_PUBMED_24101491}}
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The entry 3wh3 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/CLC4E_HUMAN CLC4E_HUMAN]] C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
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Authors: Furukawa, A., Kamishikiryo, J., Mori, D., Toyonaga, K., Okabe, Y., Toji, A., Kanda, R., Miyake, Y., Ose, T., Yamasaki, S., Maenaka, K.
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==About this Structure==
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[[3wh3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bionectria_wenpingii Bionectria wenpingii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WH3 OCA].
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Description: human Mincle, ligand free form
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==Reference==
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<ref group="xtra">PMID:024101491</ref><references group="xtra"/><references/>
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[[Category: Bionectria wenpingii]]
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[[Category: Furukawa, A.]]
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[[Category: Kamishikiryo, J.]]
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[[Category: Kanda, R.]]
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[[Category: Maenaka, K.]]
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[[Category: Miyake, Y.]]
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[[Category: Mori, D.]]
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[[Category: Okabe, Y.]]
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[[Category: Ose, T.]]
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[[Category: Toji, A.]]
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[[Category: Toyonaga, K.]]
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[[Category: Yamasaki, S.]]
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[[Category: C-type lectin]]
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[[Category: Carbohydrate recognition]]
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[[Category: Glycolipid binding]]
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[[Category: Immune system]]
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[[Category: Plasmamembrane]]

Revision as of 06:41, 23 October 2013

Template:STRUCTURE 3wh3

Contents

human Mincle, ligand free form

Template:ABSTRACT PUBMED 24101491

Function

[CLC4E_HUMAN] C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.

About this Structure

3wh3 is a 1 chain structure with sequence from Bionectria wenpingii. Full crystallographic information is available from OCA.

Reference

  • Furukawa A, Kamishikiryo J, Mori D, Toyonaga K, Okabe Y, Toji A, Kanda R, Miyake Y, Ose T, Yamasaki S, Maenaka K. Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL. Proc Natl Acad Sci U S A. 2013 Oct 7. PMID:24101491 doi:http://dx.doi.org/10.1073/pnas.1312649110

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