4bqj

From Proteopedia

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m (Protected "4bqj" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4bqj| PDB=4bqj | SCENE= }}
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===structure of HSP90 with an inhibitor bound===
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{{ABSTRACT_PUBMED_24100158}}
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The entry 4bqj is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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Authors: Casale, E., Brasca, M.G., Mantegani, S., Amboldi, N., Bindi, S., Caronni, D., Ceccarelli, W., Colombo, N., DePonti, A., Donati, D., Ermoli, A., Fachin, G., Felder, E.R., Ferguson, R.D., Fiorelli, C., Guanci, M., Isacchi, A., Pesenti, E., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Fogliatto, G.
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==About this Structure==
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[[4bqj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQJ OCA].
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Description: structure of HSP90 with an inhibitor bound
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==Reference==
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<ref group="xtra">PMID:024100158</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Amboldi, N.]]
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[[Category: Bindi, S.]]
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[[Category: Brasca, M G.]]
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[[Category: Caronni, D.]]
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[[Category: Casale, E.]]
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[[Category: Ceccarelli, W.]]
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[[Category: Colombo, N.]]
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[[Category: DePonti, A.]]
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[[Category: Donati, D.]]
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[[Category: Ermoli, A.]]
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[[Category: Fachin, G.]]
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[[Category: Felder, E R.]]
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[[Category: Ferguson, R D.]]
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[[Category: Fiorelli, C.]]
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[[Category: Fogliatto, G.]]
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[[Category: Guanci, M.]]
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[[Category: Isacchi, A.]]
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[[Category: Mantegani, S.]]
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[[Category: Pesenti, E.]]
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[[Category: Polucci, P.]]
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[[Category: Riceputi, L.]]
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[[Category: Sola, F.]]
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[[Category: Visco, C.]]
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[[Category: Zuccotto, F.]]
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[[Category: Hydrolase]]

Revision as of 06:46, 23 October 2013

Template:STRUCTURE 4bqj

Contents

structure of HSP90 with an inhibitor bound

Template:ABSTRACT PUBMED 24100158

Function

[HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.[1] [2]

About this Structure

4bqj is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Brasca MG, Mantegani S, Amboldi N, Bindi S, Caronni D, Casale E, Ceccarelli W, Colombo N, De Ponti A, Donati D, Ermoli A, Fachin G, Felder ER, Ferguson RD, Fiorelli C, Guanci M, Isacchi A, Pesenti E, Polucci P, Riceputi L, Sola F, Visco C, Zuccotto F, Fogliatto G. Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90). Bioorg Med Chem. 2013 Nov 15;21(22):7047-63. doi: 10.1016/j.bmc.2013.09.018. Epub, 2013 Sep 19. PMID:24100158 doi:http://dx.doi.org/10.1016/j.bmc.2013.09.018
  1. ↑ Martinez-Ruiz A, Villanueva L, Gonzalez de Orduna C, Lopez-Ferrer D, Higueras MA, Tarin C, Rodriguez-Crespo I, Vazquez J, Lamas S. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8525-30. Epub 2005 Jun 3. PMID:15937123 doi:10.1073/pnas.0407294102
  2. ↑ Forsythe HL, Jarvis JL, Turner JW, Elmore LW, Holt SE. Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. J Biol Chem. 2001 May 11;276(19):15571-4. Epub 2001 Mar 23. PMID:11274138 doi:10.1074/jbc.C100055200

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