4jir

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'''Unreleased structure'''
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{{STRUCTURE_4jir| PDB=4jir | SCENE= }}
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===Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Epalrestat===
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{{ABSTRACT_PUBMED_24100137}}
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The entry 4jir is ON HOLD until 00 0001
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==Function==
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[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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Authors: Zhang, L., Zheng, X., Zhang, H.., Zhao, Y., Chen, K., Zhai, J., Hu, X.
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==About this Structure==
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[[4jir]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JIR OCA].
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Description: Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Epalrestat
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==Reference==
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<ref group="xtra">PMID:024100137</ref><references group="xtra"/><references/>
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[[Category: Aldehyde reductase]]
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[[Category: Homo sapiens]]
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[[Category: Chen, K.]]
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[[Category: Hu, X.]]
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[[Category: Zhai, J.]]
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[[Category: Zhang, H..]]
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[[Category: Zhang, L.]]
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[[Category: Zhao, Y.]]
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[[Category: Zheng, X.]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Tim barrel]]

Revision as of 06:48, 23 October 2013

Template:STRUCTURE 4jir

Contents

Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Epalrestat

Template:ABSTRACT PUBMED 24100137

Function

[ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

About this Structure

4jir is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Zhang L, Zhang H, Zhao Y, Li Z, Chen S, Zhai J, Chen Y, Xie W, Wang Z, Li Q, Zheng X, Hu X. Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111). FEBS Lett. 2013 Oct 4. pii: S0014-5793(13)00726-6. doi:, 10.1016/j.febslet.2013.09.031. PMID:24100137 doi:http://dx.doi.org/10.1016/j.febslet.2013.09.031

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OCA

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