4jf3
From Proteopedia
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| - | + | {{STRUCTURE_4jf3| PDB=4jf3 | SCENE= }} | |
| + | ===Crystal structure of the mpmv tm retroviral fusion core=== | ||
| - | The | + | ==Function== |
| + | [[http://www.uniprot.org/uniprot/ENV_MPMV ENV_MPMV]] The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane (By similarity). The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity). | ||
| - | + | ==About this Structure== | |
| - | + | [[4jf3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mason-pfizer_monkey_virus Mason-pfizer monkey virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JF3 OCA]. | |
| - | + | [[Category: Mason-pfizer monkey virus]] | |
| + | [[Category: Aydin, H.]] | ||
| + | [[Category: Cook, J D.]] | ||
| + | [[Category: Lee, J E.]] | ||
| + | [[Category: Fusion]] | ||
| + | [[Category: Mpmv tm]] | ||
| + | [[Category: Six-helix bundle]] | ||
| + | [[Category: Viral protein]] | ||
| + | [[Category: Virus envelope]] | ||
Revision as of 06:53, 23 October 2013
Crystal structure of the mpmv tm retroviral fusion core
Function
[ENV_MPMV] The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane (By similarity). The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
About this Structure
4jf3 is a 2 chain structure with sequence from Mason-pfizer monkey virus. Full crystallographic information is available from OCA.
