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4luw

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4luw| PDB=4luw | SCENE= }}
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===Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3R,5S)-5-(((6-amino-4-methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine===
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The entry 4luw is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
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Authors: Li, H., Poulos, T.L.
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==About this Structure==
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[[4luw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LUW OCA].
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Description: Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3R,5S)-5-(((6-amino-4-methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine
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[[Category: Bos taurus]]
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[[Category: Li, H.]]
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[[Category: Poulos, T L.]]
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[[Category: Nitric oxide synthase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 06:55, 23 October 2013

Template:STRUCTURE 4luw

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3R,5S)-5-(((6-amino-4-methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine

Function

[NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

About this Structure

4luw is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

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OCA

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