4me7

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'''Unreleased structure'''
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{{STRUCTURE_4me7| PDB=4me7 | SCENE= }}
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===Crystal structure of Bacillus subtilis toxin MazF in complex with cognate antitoxin MazE===
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The entry 4me7 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ENDOA_BACSU ENDOA_BACSU]] Toxic component of a toxin-antitoxin (TA) module. Has specificity for UACAU sequences, claving after the first U and yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single-stranded RNA. The toxicity is reversed by the antitoxin EndoAI. Toxin activity cannot be inhibited by MazE from E.coli.<ref>PMID:15882409</ref> <ref>PMID:21763692</ref> [[http://www.uniprot.org/uniprot/ENDAI_BACSU ENDAI_BACSU]] Antitoxin component of a toxin-antitoxin (TA) module. Antitoxin that directly inhibits activity of EndoA in vitro. Upon expression in E.coli counteracts inhibitory effect of mRNA interferase EndoA.<ref>PMID:15882409</ref> <ref>PMID:21763692</ref>
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Authors: Simanshu, D.K., Patel, D.J.
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==About this Structure==
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[[4me7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ME7 OCA].
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Description: Crystal structure of Bacillus subtilis toxin MazF in complex with cognate antitoxin MazE
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Bacillus subtilis subsp. subtilis str. 168]]
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[[Category: Patel, D J.]]
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[[Category: Simanshu, D K.]]
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[[Category: Antitoxin]]
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[[Category: Endoa]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Maze]]
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[[Category: Maze-mazf]]
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[[Category: Mazf]]
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[[Category: Mrna clevage]]
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[[Category: Mrna interferase]]
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[[Category: Stress response]]
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[[Category: Toxin-antitoxin system]]
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[[Category: Ydce]]

Revision as of 06:56, 23 October 2013

Template:STRUCTURE 4me7

Contents

Crystal structure of Bacillus subtilis toxin MazF in complex with cognate antitoxin MazE

Function

[ENDOA_BACSU] Toxic component of a toxin-antitoxin (TA) module. Has specificity for UACAU sequences, claving after the first U and yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single-stranded RNA. The toxicity is reversed by the antitoxin EndoAI. Toxin activity cannot be inhibited by MazE from E.coli.[1] [2] [ENDAI_BACSU] Antitoxin component of a toxin-antitoxin (TA) module. Antitoxin that directly inhibits activity of EndoA in vitro. Upon expression in E.coli counteracts inhibitory effect of mRNA interferase EndoA.[3] [4]

About this Structure

4me7 is a 6 chain structure with sequence from Bacillus subtilis subsp. subtilis str. 168. Full crystallographic information is available from OCA.

Reference

  1. ↑ Pellegrini O, Mathy N, Gogos A, Shapiro L, Condon C. The Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor. Mol Microbiol. 2005 Jun;56(5):1139-48. PMID:15882409 doi:MMI4606
  2. ↑ Park JH, Yamaguchi Y, Inouye M. Bacillus subtilis MazF-bs (EndoA) is a UACAU-specific mRNA interferase. FEBS Lett. 2011 Aug 4;585(15):2526-32. doi: 10.1016/j.febslet.2011.07.008. Epub, 2011 Jul 13. PMID:21763692 doi:http://dx.doi.org/10.1016/j.febslet.2011.07.008
  3. ↑ Pellegrini O, Mathy N, Gogos A, Shapiro L, Condon C. The Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor. Mol Microbiol. 2005 Jun;56(5):1139-48. PMID:15882409 doi:MMI4606
  4. ↑ Park JH, Yamaguchi Y, Inouye M. Bacillus subtilis MazF-bs (EndoA) is a UACAU-specific mRNA interferase. FEBS Lett. 2011 Aug 4;585(15):2526-32. doi: 10.1016/j.febslet.2011.07.008. Epub, 2011 Jul 13. PMID:21763692 doi:http://dx.doi.org/10.1016/j.febslet.2011.07.008

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