2gwl

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m (Protected "2gwl" [edit=sysop:move=sysop])
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[[Image:2gwl.png|left|200px]]
 
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{{STRUCTURE_2gwl| PDB=2gwl | SCENE= }}
{{STRUCTURE_2gwl| PDB=2gwl | SCENE= }}
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===Crystal structure of the Salmonella SpvB ATR Domain in complex with NADH===
===Crystal structure of the Salmonella SpvB ATR Domain in complex with NADH===
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{{ABSTRACT_PUBMED_16905096}}
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{{ABSTRACT_PUBMED_16905096}}
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==Function==
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[[http://www.uniprot.org/uniprot/SPVB_SALCH SPVB_SALCH]] Mono-ADP-ribosylates eukaryotic muscle and non-muscle actin on 'Arg-177'. ADP-ribosylation prevents the polymerization of G-actin to F-actin, causing actin filament depolymerization, destruction of the cytoskeleton and cytotoxicity. Does not possess NAD(+)-glycohydrolase activity, unlike most mART enzymes (By similarity).
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:016905096</ref><references group="xtra"/>
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<ref group="xtra">PMID:016905096</ref><references group="xtra"/><references/>
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
[[Category: Margarit, S M.]]
[[Category: Margarit, S M.]]

Revision as of 08:28, 30 October 2013

Template:STRUCTURE 2gwl

Contents

Crystal structure of the Salmonella SpvB ATR Domain in complex with NADH

Template:ABSTRACT PUBMED 16905096

Function

[SPVB_SALCH] Mono-ADP-ribosylates eukaryotic muscle and non-muscle actin on 'Arg-177'. ADP-ribosylation prevents the polymerization of G-actin to F-actin, causing actin filament depolymerization, destruction of the cytoskeleton and cytotoxicity. Does not possess NAD(+)-glycohydrolase activity, unlike most mART enzymes (By similarity).

About this Structure

2gwl is a 1 chain structure with sequence from Salmonella enterica subsp. enterica serovar typhimurium. Full crystallographic information is available from OCA.

Reference

  • Margarit SM, Davidson W, Frego L, Stebbins CE. A steric antagonism of actin polymerization by a salmonella virulence protein. Structure. 2006 Aug;14(8):1219-29. PMID:16905096 doi:10.1016/j.str.2006.05.022

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OCA

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