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1arz

From Proteopedia

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m (Protected "1arz" [edit=sysop:move=sysop])
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[[Image:1arz.png|left|200px]]
 
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{{STRUCTURE_1arz| PDB=1arz | SCENE= }}
{{STRUCTURE_1arz| PDB=1arz | SCENE= }}
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===ESCHERICHIA COLI DIHYDRODIPICOLINATE REDUCTASE IN COMPLEX WITH NADH AND 2,6 PYRIDINE DICARBOXYLATE===
===ESCHERICHIA COLI DIHYDRODIPICOLINATE REDUCTASE IN COMPLEX WITH NADH AND 2,6 PYRIDINE DICARBOXYLATE===
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{{ABSTRACT_PUBMED_9398235}}
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{{ABSTRACT_PUBMED_9398235}}
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==Function==
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[[http://www.uniprot.org/uniprot/DAPB_ECOLI DAPB_ECOLI]] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. Can use both NADH and NADPH as a reductant, with NADH being twice as effective as NADPH.<ref>PMID:7893644</ref> <ref>PMID:20503968</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:009398235</ref><references group="xtra"/>
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<ref group="xtra">PMID:009398235</ref><references group="xtra"/><references/>
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[[Category: Dihydrodipicolinate reductase]]
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[[Category: 4-hydroxy-tetrahydrodipicolinate reductase]]
[[Category: Escherichia coli k-12]]
[[Category: Escherichia coli k-12]]
[[Category: Blanchard, J S.]]
[[Category: Blanchard, J S.]]

Revision as of 08:34, 30 October 2013

Template:STRUCTURE 1arz

Contents

ESCHERICHIA COLI DIHYDRODIPICOLINATE REDUCTASE IN COMPLEX WITH NADH AND 2,6 PYRIDINE DICARBOXYLATE

Template:ABSTRACT PUBMED 9398235

Function

[DAPB_ECOLI] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. Can use both NADH and NADPH as a reductant, with NADH being twice as effective as NADPH.[1] [2]

About this Structure

1arz is a 4 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

  • Scapin G, Reddy SG, Zheng R, Blanchard JS. Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase in complex with NADH and the inhibitor 2,6-pyridinedicarboxylate. Biochemistry. 1997 Dec 9;36(49):15081-8. PMID:9398235 doi:http://dx.doi.org/10.1021/bi9719915
  1. ↑ Reddy SG, Sacchettini JC, Blanchard JS. Expression, purification, and characterization of Escherichia coli dihydrodipicolinate reductase. Biochemistry. 1995 Mar 21;34(11):3492-501. PMID:7893644
  2. ↑ Devenish SR, Blunt JW, Gerrard JA. NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase. J Med Chem. 2010 Jun 24;53(12):4808-12. doi: 10.1021/jm100349s. PMID:20503968 doi:10.1021/jm100349s

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