4i02

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4i02| PDB=4i02 | SCENE= }}
 +
===structure of the mutant Catabolite gene activator protein V140A===
 +
{{ABSTRACT_PUBMED_24058293}}
-
The entry 4i02 is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI]] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
-
Authors: Pohl, E., Townsend, P.D., Rodgers, T., Burnell, D., McLeish, T.C.B., Wilson, M.R., Cann, M.J.
+
==About this Structure==
 +
[[4i02]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I02 OCA].
-
Description: structure of the mutant Catabolite gene activator protein V140A
+
==Reference==
 +
<ref group="xtra">PMID:024058293</ref><references group="xtra"/><references/>
 +
[[Category: Escherichia coli k-12]]
 +
[[Category: Burnell, D.]]
 +
[[Category: Cann, M J.]]
 +
[[Category: McLeish, T C.B.]]
 +
[[Category: Pohl, E.]]
 +
[[Category: Rodgers, T.]]
 +
[[Category: Townsend, P D.]]
 +
[[Category: Wilson, M R.]]
 +
[[Category: Dna binding]]
 +
[[Category: Transcription]]

Revision as of 09:30, 30 October 2013

Template:STRUCTURE 4i02

Contents

structure of the mutant Catabolite gene activator protein V140A

Template:ABSTRACT PUBMED 24058293

Function

[CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.[1]

About this Structure

4i02 is a 6 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

  • Rodgers TL, Townsend PD, Burnell D, Jones ML, Richards SA, McLeish TC, Pohl E, Wilson MR, Cann MJ. Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors. PLoS Biol. 2013 Sep;11(9):e1001651. doi: 10.1371/journal.pbio.1001651. Epub 2013 , Sep 10. PMID:24058293 doi:http://dx.doi.org/10.1371/journal.pbio.1001651
  1. ↑ Aiba H. Transcription of the Escherichia coli adenylate cyclase gene is negatively regulated by cAMP-cAMP receptor protein. J Biol Chem. 1985 Mar 10;260(5):3063-70. PMID:2982847

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4i02"
Personal tools