This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4msw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4msw" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4msw| PDB=4msw | SCENE= }}
 +
===Y78 ester mutant of KcsA in high K+===
 +
{{ABSTRACT_PUBMED_24128761}}
-
The entry 4msw is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
-
Authors: Matulef, K., Valiyaveetil, F.I.
+
==About this Structure==
 +
[[4msw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSW OCA].
-
Description: Y78 ester mutant of KcsA in high K+
+
==Reference==
 +
<ref group="xtra">PMID:024128761</ref><references group="xtra"/><references/>
 +
[[Category: Mus musculus]]
 +
[[Category: Streptomyces lividans]]
 +
[[Category: Matulef, K.]]
 +
[[Category: Valiyaveetil, F I.]]
 +
[[Category: Channel]]
 +
[[Category: Ester]]
 +
[[Category: Membrane protein]]
 +
[[Category: Transport protein]]
 +
[[Category: Unnatural amino acid]]

Revision as of 09:37, 30 October 2013

Template:STRUCTURE 4msw

Contents

Y78 ester mutant of KcsA in high K+

Template:ABSTRACT PUBMED 24128761

Function

[KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).[1]

About this Structure

4msw is a 3 chain structure with sequence from Mus musculus and Streptomyces lividans. Full crystallographic information is available from OCA.

Reference

  • Matulef K, Komarov AG, Costantino CA, Valiyaveetil FI. Using protein backbone mutagenesis to dissect the link between ion occupancy and C-type inactivation in K+ channels. Proc Natl Acad Sci U S A. 2013 Oct 15. PMID:24128761 doi:http://dx.doi.org/10.1073/pnas.1314356110
  1. ↑ Schrempf H, Schmidt O, Kummerlen R, Hinnah S, Muller D, Betzler M, Steinkamp T, Wagner R. A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans. EMBO J. 1995 Nov 1;14(21):5170-8. PMID:7489706

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4msw"
Personal tools