4mkp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4mkp| PDB=4mkp | SCENE= }}
 +
===Crystal structure of human cGAS apo form===
 +
{{ABSTRACT_PUBMED_24116191}}
-
The entry 4mkp is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
-
Authors: Kato, K., Ishii, R., Ishitani, R., Nureki, O.
+
==About this Structure==
 +
[[4mkp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MKP OCA].
-
Description: Crystal structure of human cGAS apo form
+
==Reference==
 +
<ref group="xtra">PMID:024116191</ref><references group="xtra"/><references/>
 +
[[Category: Homo sapiens]]
 +
[[Category: Ishii, R.]]
 +
[[Category: Ishitani, R.]]
 +
[[Category: Kato, K.]]
 +
[[Category: Nureki, O.]]
 +
[[Category: Nucleotidyltransferase]]
 +
[[Category: Transferase]]

Revision as of 09:39, 30 October 2013

Template:STRUCTURE 4mkp

Contents

Crystal structure of human cGAS apo form

Template:ABSTRACT PUBMED 24116191

Function

[CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.[1] [2]

About this Structure

4mkp is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kato K, Ishii R, Goto E, Ishitani R, Tokunaga F, Nureki O. Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS. PLoS One. 2013 Oct 7;8(10):e76983. doi: 10.1371/journal.pone.0076983. PMID:24116191 doi:http://dx.doi.org/10.1371/journal.pone.0076983
  1. ↑ Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, Rice CM. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature. 2011 Apr 28;472(7344):481-5. doi: 10.1038/nature09907. Epub 2011 Apr 10. PMID:21478870 doi:10.1038/nature09907
  2. ↑ Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012, Dec 20. PMID:23258413 doi:10.1126/science.1232458

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4mkp"
Personal tools