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4i0b

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4i0b| PDB=4i0b | SCENE= }}
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===structure of the mutant Catabolite gene activator protein H160L===
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{{ABSTRACT_PUBMED_24058293}}
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The entry 4i0b is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI]] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
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Authors: Pohl, E., Townsend, P.D., Rodgers, T., Burnell, D., McLeish, T.C.B., Wilson, M.R., Cann, M.J.
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==About this Structure==
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[[4i0b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0B OCA].
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Description: structure of the mutant Catabolite gene activator protein H160L
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==Reference==
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<ref group="xtra">PMID:024058293</ref><references group="xtra"/><references/>
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[[Category: Escherichia coli k-12]]
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[[Category: Burnell, D.]]
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[[Category: Cann, M J.]]
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[[Category: McLeish, T C.B.]]
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[[Category: Pohl, E.]]
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[[Category: Rodgers, T.]]
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[[Category: Townsend, P D.]]
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[[Category: Wilson, M R.]]
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[[Category: Dna binding]]
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[[Category: Transcription]]

Revision as of 09:41, 30 October 2013

Template:STRUCTURE 4i0b

Contents

structure of the mutant Catabolite gene activator protein H160L

Template:ABSTRACT PUBMED 24058293

Function

[CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.[1]

About this Structure

4i0b is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

  • Rodgers TL, Townsend PD, Burnell D, Jones ML, Richards SA, McLeish TC, Pohl E, Wilson MR, Cann MJ. Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors. PLoS Biol. 2013 Sep;11(9):e1001651. doi: 10.1371/journal.pbio.1001651. Epub 2013 , Sep 10. PMID:24058293 doi:http://dx.doi.org/10.1371/journal.pbio.1001651
  1. ↑ Aiba H. Transcription of the Escherichia coli adenylate cyclase gene is negatively regulated by cAMP-cAMP receptor protein. J Biol Chem. 1985 Mar 10;260(5):3063-70. PMID:2982847

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