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4j4q

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4j4q| PDB=4j4q | SCENE= }}
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===Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside===
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{{ABSTRACT_PUBMED_24038729}}
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The entry 4j4q is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref> [[http://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
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Authors: Park, J.H., Morizumi, T., Li, Y., Hong, J.E., Pai, E.F., Hofmann, K.P., Choe, H.W., Ernst, O.P.
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==About this Structure==
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[[4j4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA].
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Description: Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside
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==Reference==
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<ref group="xtra">PMID:024038729</ref><references group="xtra"/><references/>
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[[Category: Bos taurus]]
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[[Category: Choe, H W.]]
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[[Category: Ernst, O P.]]
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[[Category: Hofmann, K P.]]
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[[Category: Hong, J E.]]
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[[Category: Li, Y.]]
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[[Category: Morizumi, T.]]
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[[Category: Pai, E F.]]
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[[Category: Park, J H.]]
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[[Category: G-protein coupled receptor]]
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[[Category: Galpha subunit]]
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[[Category: Glycoprotein]]
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[[Category: Gtp-binding]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Myristate]]
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[[Category: Nucleotide-binding]]
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[[Category: Photoreceptor protein]]
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[[Category: Receptor retinal protein]]
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[[Category: Retinal binding]]
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[[Category: Sensory transduction]]
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[[Category: Signaling protein]]
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[[Category: Transducer]]
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[[Category: Transmembrane]]

Revision as of 09:44, 30 October 2013

Template:STRUCTURE 4j4q

Contents

Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside

Template:ABSTRACT PUBMED 24038729

Function

[OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).[1] [2] [GNAT1_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.

About this Structure

4j4q is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Park JH, Morizumi T, Li Y, Hong JE, Pai EF, Hofmann KP, Choe HW, Ernst OP. Opsin, a structural model for olfactory receptors? Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11021-4. doi: 10.1002/anie.201302374. , Epub 2013 Aug 26. PMID:24038729 doi:http://dx.doi.org/10.1002/anie.201302374
  1. ↑ Nakamichi H, Okada T. Local peptide movement in the photoreaction intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12729-34. Epub 2006 Aug 14. PMID:16908857
  2. ↑ Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607

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