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4lcu

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'''Unreleased structure'''
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{{STRUCTURE_4lcu| PDB=4lcu | SCENE= }}
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===Structure of KcsA with E118A mutation===
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The entry 4lcu is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
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Authors: Nimigean, C.M., Posson, D.J., McCoy, J.M.
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==About this Structure==
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[[4lcu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LCU OCA].
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Description:
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Streptomyces lividans]]
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[[Category: McCoy, J M.]]
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[[Category: Nimigean, C M.]]
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[[Category: Posson, D J.]]
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[[Category: Membrane protein]]
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[[Category: Ph-gated potassium channel]]
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[[Category: Potassium channel]]
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[[Category: Transport protein]]
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[[Category: Voltage gated potassium channel]]

Revision as of 09:53, 30 October 2013

Template:STRUCTURE 4lcu

Contents

Structure of KcsA with E118A mutation

Function

[KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).[1]

About this Structure

4lcu is a 3 chain structure with sequence from Mus musculus and Streptomyces lividans. Full crystallographic information is available from OCA.

Reference

  1. ↑ Schrempf H, Schmidt O, Kummerlen R, Hinnah S, Muller D, Betzler M, Steinkamp T, Wagner R. A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans. EMBO J. 1995 Nov 1;14(21):5170-8. PMID:7489706

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OCA

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