LaurenJansen/Sandbox1
From Proteopedia
(→Membrane Type 1 Matrix Metalloproteinase (MT1-MMP)) |
(→Membrane Type 1 Matrix Metalloproteinase (MT1-MMP)) |
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| - | ==Membrane Type 1 Matrix Metalloproteinase | + | ==Membrane Type 1 Matrix Metalloproteinase== |
One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]. | One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]. | ||
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| + | Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) is 1 of ~21 members of the human MMP family of endopeptidases. MMPs are zinc dependent proteinases that are capable of degrading virtually any extracellular matrix component. Inherently, this enables MMPs to be a key player in regulation of cell behavior. | ||
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| + | There are 8 structure classes for MMPs, of which 5 are secreted molecules and 3 are membrane-type. MT1-MMP or also known as MMP-14 is covalently bound to the cell membrane and | ||
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<Structure load='1bqq' size='200' frame='true' align='right' caption='PBD file obtained from http://pdb.org/pdb/explore/explore.do?structureId=1bqq ' scene='Insert optional scene name here' /> | <Structure load='1bqq' size='200' frame='true' align='right' caption='PBD file obtained from http://pdb.org/pdb/explore/explore.do?structureId=1bqq ' scene='Insert optional scene name here' /> | ||
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| + | ===Structure=== | ||
| + | ===Inhibition=== | ||
| + | ===Extracellular Matrix Components=== | ||
| + | ===See Also=== | ||
| + | ===References=== | ||
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| + | 1. M. Sternlicht, et al., How Matrix Metalloproteinases Regulate Cell Behavior, Annu Rev Cell Dev Biol, 2001. 17: p. 463–516. | ||
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| + | 2. L. Coussens, et al., Meatrix Metalloproteinase Inhibitors and Cancer: Trials and Tribulations | ||
Revision as of 16:58, 1 November 2013
Contents |
Membrane Type 1 Matrix Metalloproteinase
One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.
Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) is 1 of ~21 members of the human MMP family of endopeptidases. MMPs are zinc dependent proteinases that are capable of degrading virtually any extracellular matrix component. Inherently, this enables MMPs to be a key player in regulation of cell behavior.
There are 8 structure classes for MMPs, of which 5 are secreted molecules and 3 are membrane-type. MT1-MMP or also known as MMP-14 is covalently bound to the cell membrane and
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Structure
Inhibition
Extracellular Matrix Components
See Also
References
1. M. Sternlicht, et al., How Matrix Metalloproteinases Regulate Cell Behavior, Annu Rev Cell Dev Biol, 2001. 17: p. 463–516.
2. L. Coussens, et al., Meatrix Metalloproteinase Inhibitors and Cancer: Trials and Tribulations
