LaurenJansen/Sandbox1

From Proteopedia

Revision as of 17:29, 1 November 2013

Membrane Type 1 Matrix Metalloproteinase

One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground. Molecular Playground banner: "MMP-14 allowing 3D in vitro cell migration"

Structure

Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) is 1 of ~21 members of the human MMP family of endopeptidases. MMPs are zinc dependent proteinases that are capable of degrading virtually any extracellular matrix component. Inherently, this enables MMPs to be a key player in regulation of cell behavior.

There are 8 structure classes for MMPs, of which 5 are secreted molecules and 3 are membrane-type. MT1-MMP or also known as MMP-14 is covalently bound to the cell membrane and

Inhibition

Extracellular Matrix Components

My Research Interest

In the Peyton Lab I work to combine materials science with stem cell and cancer biology to design in vitro model biomaterial systems to understand cell motility. My project aims to design 3D biomaterial tissue mimics using poly(ethylene glycol) and I incorporate degradable MMP crosslinkers into these materials to allow cells the opportunity to remodel their surrounding matrix.

References

1. M. Sternlicht, et al., How Matrix Metalloproteinases Regulate Cell Behavior, Annu Rev Cell Dev Biol, 2001. 17: p. 463–516.

2. L. Coussens, et al., Meatrix Metalloproteinase Inhibitors and Cancer: Trials and Tribulations