LaurenJansen/Sandbox1
From Proteopedia
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==References== | ==References== | ||
| - | + | <ref>PMID:11687497<ref> M. Sternlicht, et al., How Matrix Metalloproteinases Regulate Cell Behavior, Annu Rev Cell Dev Biol, 2001. 17: p. 463–516. | |
| - | + | <ref> PMID:11923519<ref> L. Coussens, et al., Matrix Metalloproteinase Inhibitors and Cancer: Trials and Tribulations, Science, 2002. 295: p. 2387-92 | |
| - | + | <ref> PMID:11990853<ref> Egeblad, et. al., New Functions for the Matrix Metalloproteinases in Cancer Progression, Nat. Rev. Can., 2002, 2: 162-74 | |
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Revision as of 17:45, 1 November 2013
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Membrane Type 1 Matrix Metalloproteinase
One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground. Molecular Playground banner: "MMP-14 allows for 3D in vitro cell migration"
Structure
Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) is 1 of ~21 members of the human MMP family of endopeptidases. MMPs are zinc dependent proteinases that are capable of degrading virtually any extracellular matrix component. Inherently, this enables MMPs to be a key player in regulation of cell behavior.
There are 8 structure classes for MMPs, of which 5 are secreted molecules and 3 are membrane-type. MT1-MMP or also known as MMP-14 is covalently bound to the cell membrane and
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Inhibition
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