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2yov

From Proteopedia

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m (Protected "2yov" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_2yov| PDB=2yov | SCENE= }}
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===Neuronal calcium sensor (NCS-1)from Rattus norvegicus===
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The entry 2yov is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NCS1_RAT NCS1_RAT]] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.<ref>PMID:17502602</ref>
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Authors: Saleem, M., Karuppiah, V., Derrick, J.P., Pandalaneni, S., Burgoyne, R., Lian, L.Y.
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==About this Structure==
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[[2yov]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOV OCA].
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Description: Neuronal calcium sensor (NCS-1)from Rattus norvegicus
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Rattus norvegicus]]
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[[Category: Burgoyne, R.]]
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[[Category: Derrick, J P.]]
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[[Category: Karuppiah, V.]]
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[[Category: Lian, L Y.]]
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[[Category: Pandalaneni, S.]]
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[[Category: Saleem, M.]]
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[[Category: Calcium-binding protein]]

Revision as of 07:35, 6 November 2013

Template:STRUCTURE 2yov

Contents

Neuronal calcium sensor (NCS-1)from Rattus norvegicus

Function

[NCS1_RAT] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.[1]

About this Structure

2yov is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Gambino F, Pavlowsky A, Begle A, Dupont JL, Bahi N, Courjaret R, Gardette R, Hadjkacem H, Skala H, Poulain B, Chelly J, Vitale N, Humeau Y. IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation. Proc Natl Acad Sci U S A. 2007 May 22;104(21):9063-8. Epub 2007 May 14. PMID:17502602 doi:http://dx.doi.org/10.1073/pnas.0701133104

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OCA

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