4hop

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'''Unreleased structure'''
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{{STRUCTURE_4hop| PDB=4hop | SCENE= }}
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===Crystal structure of the computationally designed NNOS-Syntrophin complex===
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The entry 4hop is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/SNTA1_MOUSE SNTA1_MOUSE]] Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate. [[http://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
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Authors: Harwood, I.M., Melero, C., Ollikainen, N., Kortemme, T.
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==About this Structure==
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[[4hop]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HOP OCA].
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Description: Crystal structure of the computationally designed NNOS-Syntrophin complex
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[[Category: Mus musculus]]
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[[Category: Rattus norvegicus]]
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[[Category: Harwood, I M.]]
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[[Category: Kortemme, T.]]
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[[Category: Melero, C.]]
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[[Category: Ollikainen, N.]]
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[[Category: Dimerization]]
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[[Category: Membrane]]
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[[Category: Membrane protein-oxidoreductase complex]]
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[[Category: Mutation]]
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[[Category: Pdz]]
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[[Category: Protein binding]]

Revision as of 07:40, 6 November 2013

Template:STRUCTURE 4hop

Crystal structure of the computationally designed NNOS-Syntrophin complex

Function

[SNTA1_MOUSE] Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate. [NOS1_RAT] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.

About this Structure

4hop is a 6 chain structure with sequence from Mus musculus and Rattus norvegicus. Full crystallographic information is available from OCA.

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