4kh6

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'''Unreleased structure'''
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{{STRUCTURE_4kh6| PDB=4kh6 | SCENE= }}
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===Toxoplasma gondii NTPDase1 C258S/C268S E493G crystallized with Mg and AMPNP===
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{{ABSTRACT_PUBMED_24115522}}
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The entry 4kh6 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NTP2_TOXGO NTP2_TOXGO]] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite. NTPAse-II has a specific activity 4.5-fold lower than NTPAse-I in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP).
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Authors: Krug, U., Totzauer, R., Strater, N.
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==About this Structure==
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[[4kh6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KH6 OCA].
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Description: Toxoplasma gondii NTPDase1 C258S/C268S E493G crystallized with Mg and AMPNP
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==Reference==
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<ref group="xtra">PMID:024115522</ref><references group="xtra"/><references/>
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[[Category: Nucleoside-triphosphatase]]
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[[Category: Toxoplasma gondii]]
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[[Category: Krug, U.]]
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[[Category: Strater, N.]]
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[[Category: Totzauer, R.]]
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[[Category: Actin-like fold]]
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[[Category: Hydrolase]]

Revision as of 07:46, 6 November 2013

Template:STRUCTURE 4kh6

Contents

Toxoplasma gondii NTPDase1 C258S/C268S E493G crystallized with Mg and AMPNP

Template:ABSTRACT PUBMED 24115522

Function

[NTP2_TOXGO] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite. NTPAse-II has a specific activity 4.5-fold lower than NTPAse-I in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP).

About this Structure

4kh6 is a 2 chain structure with sequence from Toxoplasma gondii. Full crystallographic information is available from OCA.

Reference

  • Krug U, Totzauer R, Zebisch M, Strater N. The ATP/ADP Substrate Specificity Switch between Toxoplasma gondii NTPDase1 and NTPDase3 is Caused by an Altered Mode of Binding of the Substrate Base. Chembiochem. 2013 Oct 2. doi: 10.1002/cbic.201300441. PMID:24115522 doi:http://dx.doi.org/10.1002/cbic.201300441

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